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Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ
Abstract
The REV3 and REV7 genes of the yeast Saccharomyces cerevisiae are required for DNA damage-induced mutagenesis. The Rev3 and Rev7 proteins were shown to form a complex with DNA polymerase activity. This polymerase replicated past a thymine-thymine cis-syn cyclobutane dimer, a lesion that normally severely inhibits replication, with an efficiency of ∼10 percent. In contrast, bypass replication efficiency with yeast DNA polymerase α was no more than 1 percent. The Rev3-Rev7 complex is the sixth eukaryotic DNA polymerase to be described, and is therefore called DNA polymerase ζ.
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Citations
Cited by
UV-induced DNA damage and repair: a review
Sinha, R. P., & Häder, D.-P. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b201230h · Cited by 1,978
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292
Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W., & Friend, S. H. (1997) · Science · doi:10.1126/science.278.5340.1064 · Cited by 773
Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη
Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.283.5404.1001 · Cited by 736
Metadata
- Authors
- Nelson, J. R., Lawrence, C. W., & Hinkle, D. C.
- Venue
- Science
- Published
- 1996-06-14
- Volume
- 272
- Issue
- 5268
- Pages
- 1646-1649
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062487397
- Cited by
- 654
- References
- 0
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996). Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ. Science. https://doi.org/10.1126/science.272.5268.1646
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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