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Three-Dimensional Structure of Human Serum Albumin

Open access
Carter, Daniel C., He, Xiao-Min, Munson, Sibyl H., Twigg, Pamela D., Gernert, Kim M., Broom, M. Beth, Miller, Teresa Y.·1989·Science

Abstract

The three-dimensional structure of human serum albumin has been solved at 6.0 angstrom (Å) resolution by the method of multiple isomorphous replacement. Crystals were grown from solutions of polyethylene glycol in the infrequently observed space group P 42 1 2 (unit cell constants a = b = 186.5 ± 0.5 Å and c = 81.0 ± 0.5 Å) and diffracted x-rays to lattice d -spacings of less than 2.9 A. The electron density maps are of high quality and revealed the structure as a predominantly α-helical globin protein in which the course of the polypeptide can be traced. The binding loci of several organic compounds have been determined.

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Metadata

Authors
Carter, D. C., He, X.-M., Munson, S. H., Twigg, P. D., Gernert, K. M., Broom, M. B., & Miller, T. Y.
Venue
Science
Published
1989-06-09
Volume
244
Issue
4909
Pages
1195-1198
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2042391719
Cited by
602
References
0
FWCI
7.07
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Three-Dimensional Structure of Human Serum Albumin. https://app.cochat.ai/papers/10.1126/science.2727704
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Carter, D. C., He, X.-M., Munson, S. H., Twigg, P. D., Gernert, K. M., Broom, M. B., & Miller, T. Y. (1989). Three-Dimensional Structure of Human Serum Albumin. Science. https://doi.org/10.1126/science.2727704

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.