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Three-Dimensional Structure of Human Serum Albumin
Open accessAbstract
The three-dimensional structure of human serum albumin has been solved at 6.0 angstrom (Å) resolution by the method of multiple isomorphous replacement. Crystals were grown from solutions of polyethylene glycol in the infrequently observed space group P 42 1 2 (unit cell constants a = b = 186.5 ± 0.5 Å and c = 81.0 ± 0.5 Å) and diffracted x-rays to lattice d -spacings of less than 2.9 A. The electron density maps are of high quality and revealed the structure as a predominantly α-helical globin protein in which the course of the polypeptide can be traced. The binding loci of several organic compounds have been determined.
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Citations
Cited by
Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
Kratz, F. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.05.010 · Cited by 2,151
The Three Recombinant Domains of Human Serum Albumin
Dockal, M., Carter, D. C., & Rüker, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29303 · Cited by 396
Self-citationCurrent issues in measurement and reporting of urinary albumin excretion
Miller, W. G., Bruns, D. E., Hortin, G. L., Sandberg, S., Aakre, K. M., McQueen, M. J., Itoh, Y., Lieske, J. C., Seccombe, D. W., Jones, G., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.106567 · Cited by 381
Interactive Association of Drugs Binding to Human Serum Albumin
Yang, F., Zhang, Y., & Liang, H. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15033580 · Cited by 376
Soeters, P., Von Meyenfeldt, M., Meijerink, W. H. J., Fredrix, E. H. M., Wouters, E. M., Schols, A. W. J., Williams, W. R., Pawlowicz, A., Davies, B., De Lor Geril, M., et al. (1990) · The Lancet · doi:10.1016/0140-6736(90)90633-g · Cited by 53
Metadata
- Authors
- Carter, D. C., He, X.-M., Munson, S. H., Twigg, P. D., Gernert, K. M., Broom, M. B., & Miller, T. Y.
- Venue
- Science
- Published
- 1989-06-09
- Volume
- 244
- Issue
- 4909
- Pages
- 1195-1198
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042391719
- Cited by
- 602
- References
- 0
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Carter, D. C., He, X.-M., Munson, S. H., Twigg, P. D., Gernert, K. M., Broom, M. B., & Miller, T. Y. (1989). Three-Dimensional Structure of Human Serum Albumin. Science. https://doi.org/10.1126/science.2727704
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.