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Making DNA Add
Abstract
Recent studies have demonstrated the feasibility of using DNA-based experiments to compute solutions to combinatorial problems. However, a prerequisite for designing a computer useful in a wide range of applications is the ability to perform mathematical calculations. The development of a DNA-based algorithm for addition is presented. The DNA representation of two nonnegative binary numbers is presented in a form permitting a chain of primer extension reactions to carry out the addition operation. To demonstrate the feasibility of this algorithm, a simple example was executed biochemically.
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Citations
Cited by
Molecular Computation by DNA Hairpin Formation
Sakamoto, K., Gouzu, H., Komiya, K., Kiga, D., Yokoyama, S., Yokomori, T., & Hagiya, M. (2000) · Science · doi:10.1126/science.288.5469.1223 · Cited by 388
Molecular computation: RNA solutions to chess problems
Faulhammer, D., Cukras, A. R., Lipton, R. J., & Landweber, L. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1385 · Cited by 338
Binary DNA Nanostructures for Data Encryption
Halvorsen, K., & Wong, W. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044212 · Cited by 45
Metadata
- Authors
- Guarnieri, F., Fliss, M., & Bancroft, C.
- Venue
- Science
- Published
- 1996-07-12
- Volume
- 273
- Issue
- 5272
- Pages
- 220-223
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985073670
- Cited by
- 189
- References
- 0
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Making DNA Add. https://app.cochat.ai/papers/10.1126/science.273.5272.220
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- Guarnieri, F., Fliss, M., & Bancroft, C. (1996). Making DNA Add. Science. https://doi.org/10.1126/science.273.5272.220
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
