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Role of the Yersinia pestis Hemin Storage ( hms ) Locus in the Transmission of Plague by Fleas

Hinnebusch, B. Joseph, Perry, Robert D., Schwan, Tom G.·1996·Science
DOI 10.1126/science.273.5273.367
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Abstract

Yersinia pestis , the cause of bubonic plague, is transmitted by the bites of infected fleas. Biological transmission of plague depends on blockage of the foregut of the flea by a mass of plague bacilli. Blockage was found to be dependent on the hemin storage ( hms ) locus. Yersinia pestis hms mutants established long-term infection of the flea's midgut but failed to colonize the proventriculus, the site in the foregut where blockage normally develops. Thus, the hms locus markedly alters the course of Y. pestis infection in its insect vector, leading to a change in blood-feeding behavior and to efficient transmission of plague.

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Research works printed but not linked: 27

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Metadata

Authors
Hinnebusch, B. J., Perry, R. D., & Schwan, T. G.
Affiliations
  • B. J. Hinnebusch and T. G. Schwan, Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
  • R. D. Perry, Department of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536-0084, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-07-19
Volume
273
Issue
5273
Pages
367-370
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.273.5273.367
Cited by
297
References
0
Language
en

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CoChat. (2026). Citation check: Role of the Yersinia pestis Hemin Storage ( hms ) Locus in the Transmission of Plague by Fleas. https://app.cochat.ai/papers/10.1126/science.273.5273.367
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Hinnebusch, B. J., Perry, R. D., & Schwan, T. G. (1996). Role of the Yersinia pestis Hemin Storage ( hms ) Locus in the Transmission of Plague by Fleas. Science. https://doi.org/10.1126/science.273.5273.367