The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genome Sequence of a Human Tumorigenic Poxvirus: Prediction of Specific Host Response-Evasion Genes
Abstract
Molluscum contagiosum virus (MCV) commonly causes asymptomatic cutaneous neoplasms in children and sexually active adults as well as persistent opportunistic acquired immunodeficiency syndrome (AIDS)-associated disease. Sequencing the 190-kilobase pair genome of MCV has now revealed that the virus potentially encodes 163 proteins, of which 103 have homologs in the smallpox virus. MCV lacks counterparts to 83 genes of the smallpox virus, including those important in suppression of host responses to infection, nucleotide biosynthesis, and cell proliferation. MCV possesses 59 genes that are predicted to encode previously uncharacterized proteins, including major histocompatibility complex class I, chemokine, and glutathione peroxidase homologs, which suggests that there are MCV-specific strategies for coexistence with the human host.
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Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
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Viral Subversion of the Immune System
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Metadata
- Authors
- Senkevich, T. G., Bugert, J. J., Sisler, J. R., Koonin, E. V., Darai, G., & Moss, B.
- Venue
- Science
- Published
- 1996-08-09
- Volume
- 273
- Issue
- 5276
- Pages
- 813-816
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2130412866
- Cited by
- 327
- References
- 1
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Senkevich, T. G., Bugert, J. J., Sisler, J. R., Koonin, E. V., Darai, G., & Moss, B. (1996). Genome Sequence of a Human Tumorigenic Poxvirus: Prediction of Specific Host Response-Evasion Genes. Science. https://doi.org/10.1126/science.273.5276.813
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
