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Regulation of Integrin Function by the Urokinase Receptor
Abstract
Integrin function is central to inflammation, immunity, and tumor progression. The urokinase-type plasminogen activator receptor (uPAR) and integrins formed stable complexes that both inhibited native integrin adhesive function and promoted adhesion to vitronectin via a ligand binding site on uPAR. Interaction of soluble uPAR with the active conformer of integrins mimicked the inhibitory effects of membrane uPAR. Both uPAR-mediated adhesion and altered integrin function were blocked by a peptide that bound to uPAR and disrupted complexes. These data provide a paradigm for regulation of integrins in which a nonintegrin membrane receptor interacts with and modifies the function of activated integrins.
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Citations
Cited by
Regulation of cell signalling by uPAR
Smith, H. W., & Marshall, C. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2821 · Cited by 960
Aplin, A. E., Howe, A., Alahari, S. K., & Juliano, R. L. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01359-0 · Cited by 847
Integrin Signaling: The Platelet Paradigm
Shattil, S. J., Kashiwagi, H., & Pampori, N. (1998) · Blood · doi:10.1182/blood.v91.8.2645.2645_2645_2657 · Cited by 665
Ghiso, J. A. A., Kovalski, K., & Ossowski, L. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.89 · Cited by 549
Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion
Bellail, A. C., Hunter, S. B., Brat, D. J., Tan, C., & Van Meir, E. G. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.013 · Cited by 526
Metadata
- Authors
- Wei, Y., Lukashev, M., Simon, D. I., Bodary, S. C., Rosenberg, S., Doyle, M. V., & Chapman, H. A.
- Venue
- Science
- Published
- 1996-09-13
- Volume
- 273
- Issue
- 5281
- Pages
- 1551-1555
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003593894
- Cited by
- 727
- References
- 0
- FWCI
- 26.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wei, Y., Lukashev, M., Simon, D. I., Bodary, S. C., Rosenberg, S., Doyle, M. V., & Chapman, H. A. (1996). Regulation of Integrin Function by the Urokinase Receptor. Science. https://doi.org/10.1126/science.273.5281.1551
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
