The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide
Abstract
The neuropeptide corticotropin-releasing factor (CRF) is well known to act on the central nervous system in ways that mimic stress and result in decreases in exploration, increases in sympathetic activity, decreases in parasympathetic outflow, and decreases in appetitive behavior. Urocortin, a neuropeptide related to CRF, binds with high affinity to the CRF 2 receptor, is more potent than CRF in suppressing appetite, but is less potent than CRF in producing anxiety-like effects and activation. Doses as low as 10 nanograms injected intracerebroventricularly were effective in decreasing food intake in food-deprived and free-feeding rats. These results suggest that urocortin may be an endogenous CRF-like factor in the brain responsible for the effects of stress on appetite.
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Chang, C.-P., Pearse, R. V., O'Connell, S., & Rosenfeld, M. G. (1993) · Neuron · doi:10.1016/0896-6273(93)90230-o · Cited by 537
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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270
Self-citationAffective consciousness: core emotional feelings in animals and humans.
Panksepp, J. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2004.10.004 · Cited by 1,217
Reyes, T. M., Lewis, K., Perrin, M. H., Kunitake, K. S., Vaughan, J., Arias, C. A., Hogenesch, J. B., Gulyas, J., Rivier, J., Vale, W. W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051626398 · Cited by 887
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Metadata
- Authors
- Spina, M., Merlo-Pich, E., Chan, R. K. W., Basso, A. M., Rivier, J., Vale, W., & Koob, G. F.
- Venue
- Science
- Published
- 1996-09-13
- Volume
- 273
- Issue
- 5281
- Pages
- 1561-1564
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964889875
- Cited by
- 564
- References
- 2
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spina, M., Merlo-Pich, E., Chan, R. K. W., Basso, A. M., Rivier, J., Vale, W., & Koob, G. F. (1996). Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide. Science. https://doi.org/10.1126/science.273.5281.1561
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