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CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40
Abstract
The role of CD40 ligand (CD40L) in the primary activation of T cells is not clear. The cellular and humoral immune responses to adenoviral vectors in a murine model of liver-directed gene transfer were studied to define the mechanisms responsible for CD40L-dependent T cell priming. CD40L-deficient mice did not develop effective cytotoxic T cells to transduced hepatocytes, and T cell-dependent B cell responses were absent. Full reconstitution of cellular and humoral immunity was achieved in CD40L-deficient mice by administration of an activating antibody to CD40 that increased expression of B7.2 on spleen cells. Wild-type mice could be made nonresponsive to vector by administration of antibodies to B7. Thus, CD40L-dependent activation of T cells occurs through signaling of CD40 in the antigen-presenting cell to enhance requisite costimulatory pathways that include B7.
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Citations
Cited by
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
Ridge, J. P., Di Rosa, F., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,342
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
Bennett, S. R. M., Carbone, F. R., Karamalis, F., Flavell, R. A., Miller, J. F. A. P., & Heath, W. R. (1998) · Nature · doi:10.1038/30996 · Cited by 2,092
CD40 AND CD154 IN CELL-MEDIATED IMMUNITY
Grewal, I. S., & Flavell, R. A. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.111 · Cited by 1,539
CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
Kirk, A. D., Harlan, D. M., Armstrong, N. N., Davis, T. A., Dong, Y., Gray, G. S., Hong, X., Thomas, D., Fechner, J. H., & Knechtle, S. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8789 · Cited by 929
Metadata
- Authors
- Yang, Y., & Wilson, J. M.
- Venue
- Science
- Published
- 1996-09-27
- Volume
- 273
- Issue
- 5283
- Pages
- 1862-1864
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067701958
- Cited by
- 427
- References
- 0
- FWCI
- 16.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, Y., & Wilson, J. M. (1996). CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40. Science. https://doi.org/10.1126/science.273.5283.1862
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
