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Adipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity
Abstract
Adipsin is a serine protease that is secreted by adipocytes into the bloodstream; it is deficient in several animal models of obesity, representing a striking example of defective gene expression in this disorder. Recombinant mouse adipsin was purified and its biochemical and enzymatic properties were studied in order to elucidate the function of this protein. Activated adipsin has little or no proteolytic activity toward most substrates but has the same activity as human complement factor D, cleaving complement factor B when it is complexed with activated complement component C3. Like authentic factor D, adipsin can activate the alternative pathway of complement, resulting in red blood cell lysis. Decreased (58 to 80 percent) complement factor D activity, relative to lean controls, was observed as a common feature of several experimental models of obesity, including the ob / ob , db / db , and monosodium glutamate (MSG)-injected mouse and the fa / fa rat. These results suggest that adipsin and the alternative pathway of complement may play an unexpected but important role in the regulation of systemic energy balance in vivo.
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Cites
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
Cited by
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Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Self-citationAdipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
PPARγ, the ultimate thrifty gene
Auwerx, J. (1999) · Diabetologia · doi:10.1007/s001250051268 · Cited by 612
The secretory function of adipocytes in the physiology of white adipose tissue
Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318
Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.
Spiegelman, B. M., Choy, L., Hotamisligil, G. S., Graves, R. A., & Tontonoz, P. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53107-0 · Cited by 277
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Metadata
- Authors
- Rosen, B. S., Cook, K. S., Yaglom, J., Groves, D. L., Volanakis, J. E., Damm, D., White, T., & Spiegelman, B. M.
- Venue
- Science
- Published
- 1989-06-23
- Volume
- 244
- Issue
- 4911
- Pages
- 1483-1487
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053633351
- Cited by
- 310
- References
- 1
- FWCI
- 8.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosen, B. S., Cook, K. S., Yaglom, J., Groves, D. L., Volanakis, J. E., Damm, D., White, T., & Spiegelman, B. M. (1989). Adipsin and Complement Factor D Activity: An Immune-Related Defect in Obesity. Science. https://doi.org/10.1126/science.2734615
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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