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Cited by 392Neuroscience and Neuropharmacology ResearchIon channel regulation and functionReceptor Mechanisms and Signaling

The DOI matches its Crossref record; 42 of the 45 references it cites were found in a registry or an index.

Presynaptic Calcium Current Modulation by a Metabotropic Glutamate Receptor

Takahashi, Tomoyuki, Forsythe, Ian D., Tsujimoto, Tetsuhiro, Barnes-Davies, Margaret, Onodera, Kayoko·1996·Science
DOI 10.1126/science.274.5287.594
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Abstract

Metabotropic glutamate receptors (mGluRs) regulate transmitter release at mammalian central synapses. However, because of the difficulty of recording from mammalian presynaptic terminals, the mechanism underlying mGluR-mediated presynaptic inhibition is not known. Here, simultaneous recordings from a giant presynaptic terminal, the calyx of Held, and its postsynaptic target in the medial nucleus of the trapezoid body were obtained in rat brainstem slices. Agonists of mGluRs suppressed a high voltage-activated P/Q-type calcium conductance in the presynaptic terminal, thereby inhibiting transmitter release at this glutamatergic synapse. Because several forms of presynaptic modulation and plasticity are mediated by mGluRs, this identification of a target ion channel is a first step toward elucidation of their molecular mechanism.

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Research works printed but not linked: 9

  1. Baskys A., Malenka R. C., ibid. 444, 687 (1991).
  2. Takahashi T., Momiyama A., Cull-Candy S. G., J. Physiol. (London) 446, 549P (1992).
  3. Sahara Y., Westbrook G. L., ibid. 13, 3041 (1993).
  4. Poncer J.-C., Shinozaki H., Miles R., ibid. 485, 121 (1995);
  5. Llano I., Marty A., ibid. 486, 163 (1995).
  6. Katz B., Miledi R., ibid. 192, 407 (1967);
  7. Kawai N., Niwa A., ibid. 305, 73 (1980).
  8. Martin A. R., Pilar G., ibid. 168, 443 (1963);
  9. Borst J. G. G., Helmchen F., Sakmann B., ibid. 489, 825 (1995).

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Metadata

Authors
Takahashi, T., Forsythe, I. D., Tsujimoto, T., Barnes-Davies, M., & Onodera, K.
Affiliations
  • The University of Tokyo (JP)
  • University of Leicester (GB)
  • I. D. Forsythe and M. Barnes-Davies, Ion Channel Group, Department of Cell Physiology and Pharmacology, University of Leicester, Post Office Box 138, Leicester LE1 9HN, UK.
Corresponding author
Takahashi, Tomoyuki
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-10-25
Volume
274
Issue
5287
Pages
594-597
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.274.5287.594
OpenAlex
W2014492558
Cited by
392
References
45
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 16
FWCI
12.15
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Funders
Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
metabotropic glutamate receptors, presynaptic inhibition, calyx of Held, P/Q-type calcium channels, presynaptic calcium currents, glutamatergic synapses, neurotransmitter release, medial nucleus of the trapezoid body, ion channel modulation
MeSH terms
Aminobutyrates, Animals, Brain Stem, Cadmium, Calcium, Calcium Channel Blockers, Synaptic Transmission, Potassium, Synapses, Calcium Channels, Potassium Channels, Rats, Wistar, Presynaptic Terminals, Receptors, Metabotropic Glutamate, Neurotransmitter Agents, Patch-Clamp Techniques, Excitatory Amino Acid Agonists, Rats, In Vitro Techniques

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