The DOI matches its Crossref record.
A Role for Phosphoinositide 3-Kinase in Bacterial Invasion
Abstract
Listeria monocytogenes is a bacterial pathogen that invades cultured nonphagocytic cells. Inhibitors and a dominant negative mutation were used to demonstrate that efficient entry requires the phosphoinositide (PI) 3-kinase p85α-p110. Infection with L. monocytogenes caused rapid increases in cellular amounts of PI(3,4)P 2 and PI(3,4,5)P 3 , indicating that invading bacteria stimulated PI 3-kinase activity. This stimulation required the bacterial protein InlB, host cell tyrosine phosphorylation, and association of p85α with one or more tyrosine-phosphorylated proteins. This role for PI 3-kinase in bacterial entry may have parallels in some endocytic events.
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Citations
Cited by
Navarre, W. W., & Schneewind, O. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.174-229.1999 · Cited by 1,391
Bacterial Adhesion and Entry into Host Cells
Pizarro-Cerdá, J., & Cossart, P. (2006) · Cell · doi:10.1016/j.cell.2006.02.012 · Cited by 977
“Integrity of lipids rafts is also required for the InlB-dependent pathway; however, in contrast to the InlA/E-cadherin case, it is not the initial interaction be-tween InlB and Met that is favored by lipid rafts, but the signaling downstream of PI3K activation (Seveau et al., 2004).”
InfluentialSelf-citationType 1 pilus-mediated bacterial invasion of bladder epithelial cells
Martinez, J. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.12.2803 · Cited by 758
Exploitation of Mammalian Host Cell Functions by Bacterial Pathogens
Finlay, B. B., & Cossart, P. (1997) · Science · doi:10.1126/science.276.5313.718 · Cited by 746
Self-citationInlB-Dependent Internalization of Listeria Is Mediated by the Met Receptor Tyrosine Kinase
Shen, Y., Naujokas, M., Park, M., & Ireton, K. (2000) · Cell · doi:10.1016/s0092-8674(00)00141-0 · Cited by 523
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Metadata
- Authors
- Ireton, K., Payrastre, B., Chap, H., Ogawa, W., Sakaue, H., Kasuga, M., & Cossart, P.
- Venue
- Science
- Published
- 1996-11
- Volume
- 274
- Issue
- 5288
- Pages
- 780-782
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042181517
- Cited by
- 335
- References
- 0
- FWCI
- 27.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ireton, K., Payrastre, B., Chap, H., Ogawa, W., Sakaue, H., Kasuga, M., & Cossart, P. (1996). A Role for Phosphoinositide 3-Kinase in Bacterial Invasion. Science. https://doi.org/10.1126/science.274.5288.780
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
