The DOI matches its Crossref record.
High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens
Abstract
Here it is reported that the incidence of mutators among isolates of pathogenic Escherichia coli and Salmonella enterica is high (over 1 percent). These findings counter the theory, founded on studies with laboratory-attenuated strains, that suggests mutators are rare among bacterial populations. Defects in methyl-directed mismatch repair underlie all mutator phenotypes described here. Of nine independently derived hypermutable strains, seven contained a defective mutS allele. Because these mutant alleles increase the mutation rate and enhance recombination among diverse species, these studies may help explain both the rapid emergence of antibiotic resistance and the penetrance of virulence genes within the prokaryotic community.
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Cited by
Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932
Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386
Evolution of high mutation rates in experimental populations of E. coli
Sniegowski, P. D., Gerrish, P. J., & Lenski, R. E. (1997) · Nature · doi:10.1038/42701 · Cited by 879
Thinking about Bacterial Populations as Multicellular Organisms
Shapiro, J. A. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.81 · Cited by 876
Lee, H., Popodi, E., Tang, H., & Foster, P. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1210309109 · Cited by 681
Metadata
- Authors
- LeClerc, J. E., Li, B., Payne, W. L., & Cebula, T. A.
- Venue
- Science
- Published
- 1996-11-15
- Volume
- 274
- Issue
- 5290
- Pages
- 1208-1211
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2153303237
- Cited by
- 817
- References
- 0
- FWCI
- 21.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- LeClerc, J. E., Li, B., Payne, W. L., & Cebula, T. A. (1996). High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens. Science. https://doi.org/10.1126/science.274.5290.1208
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
