The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Associative Learning Disrupted by Impaired G s Signaling in Drosophila Mushroom Bodies
Abstract
Disruptions in mushroom body (MB) or central complex (CC) brain structures impair Drosophila associative olfactory learning. Perturbations in adenosine 3′,5′ monophosphate signaling also disrupt learning. To integrate these observations, expression of a constitutively activated stimulatory heterotrimeric guanosine triphosphate-binding protein α subunit (Gα s *) was targeted to these brain structures. The ability to associate odors with electroshock was abolished when Gα s * was targeted to MB, but not CC, structures, whereas sensorimotor responses to these stimuli remained normal. Expression of Gα s * did not affect gross MB morphology, and wild-type Gα s expression did not affect learning. Thus, olfactory learning depends on regulated G s signaling in Drosophila MBs.
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The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Sweeney, S. T., Broadie, K., Keane, J., Niemann, H., & O'Kane, C. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90290-2 · Cited by 938
Self-citationGenetic dissection of consolidated memory in Drosophila
Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924
Self-citationLivingstone, M. S., Sziber, P. P., & Quinn, W. G. (1984) · Cell · doi:10.1016/0092-8674(84)90316-7 · Cited by 587
The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase
Levin, L. R., Han, P.-L., Hwang, P. M., Feinstein, P. G., Davis, R. L., & Reed, R. R. (1992) · Cell · doi:10.1016/0092-8674(92)90185-f · Cited by 517
Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice.
Wu, Z. L., Thomas, S. A., Villacres, E. C., Xia, Z., Simmons, M. L., Chavkin, C., Palmiter, R. D., & Storm, D. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.1.220 · Cited by 370
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Mushroom body memoir: from maps to models
Heisenberg, M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1074 · Cited by 1,286
Schwaerzel, M., Monastirioti, M., Scholz, H., Friggi-Grelin, F., Birman, S., & Heisenberg, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10495.2003 · Cited by 871
A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila
Krashes, M. J., DasGupta, S., Vreede, A., White, B., Armstrong, J. D., & Waddell, S. (2009) · Cell · doi:10.1016/j.cell.2009.08.035 · Cited by 598
Self-citationRandom convergence of olfactory inputs in the Drosophila mushroom body
Caron, S. J. C., Ruta, V., Abbott, L. F., & Axel, R. (2013) · Nature · doi:10.1038/nature12063 · Cited by 409
Neuronal assemblies of the Drosophila mushroom body
Tanaka, N. K., Tanimoto, H., & Ito, K. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21692 · Cited by 470
Metadata
- Authors
- Connolly, J. B., Roberts, I. J. H., Armstrong, J. D., Kaiser, K., Forte, M., Tully, T., & O'Kane, C. J.
- Venue
- Science
- Published
- 1996-12-20
- Volume
- 274
- Issue
- 5295
- Pages
- 2104-2107
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2121339588
- Cited by
- 496
- References
- 6
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Connolly, J. B., Roberts, I. J. H., Armstrong, J. D., Kaiser, K., Forte, M., Tully, T., & O'Kane, C. J. (1996). Associative Learning Disrupted by Impaired G s Signaling in Drosophila Mushroom Bodies. Science. https://doi.org/10.1126/science.274.5295.2104
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
