The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature
Abstract
Selective occlusion of tumor vasculature was tested as a therapy for solid tumors in a mouse model. The formation of blood clots (thrombosis) within the tumor vessels was initiated by targeting the cell surface domain of human tissue factor, by means of a bispecific antibody, to an experimentally induced marker on tumor vascular endothelial cells. This truncated form of tissue factor (tTF) had limited ability to initiate thrombosis when free in the circulation, but became an effective and selective thrombogen when targeted to tumor endothelial cells. Intravenous administration of the antibody-tTF complex to mice with large neuroblastomas resulted in complete tumor regressions in 38 percent of the mice.
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Cites
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Self-citationVascular attack as a therapeutic strategy for cancer
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Cited by
Angiogenesis in cancer and other diseases
Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070
Improving the efficacy of antibody-based cancer therapies
Carter, P. (2001) · Nature Reviews Cancer · doi:10.1038/35101072 · Cited by 833
Siemann, D. W. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2010.05.001 · Cited by 611
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Design and Use of a Phage Display Library
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Metadata
- Authors
- Huang, X., Molema, G., King, S., Watkins, L., Edgington, T. S., & Thorpe, P. E.
- Venue
- Science
- Published
- 1997-01-24
- Volume
- 275
- Issue
- 5299
- Pages
- 547-550
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067593747
- Cited by
- 477
- References
- 17
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, X., Molema, G., King, S., Watkins, L., Edgington, T. S., & Thorpe, P. E. (1997). Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature. Science. https://doi.org/10.1126/science.275.5299.547
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
