The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy
Open accessAbstract
Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6-hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.
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Citations
Cites
Functional recovery in parkinsonian monkeys treated with GDNF
Gash, D. M., Zhang, Z., Ovadia, A., Cass, W. A., Yi, A., Simmerman, L., Russell, D., Martin, D., Lapchak, P. A., Collins, F., et al. (1996) · Nature · doi:10.1038/380252a0 · Cited by 955
Cited by
Kordower, J. H., Emborg, M. E., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J., Chen, E.-Y., Palfi, S., Roitberg, B. Z., et al. (2000) · Science · doi:10.1126/science.290.5492.767 · Cited by 1,251
Prospects for new restorative and neuroprotective treatments in Parkinson's disease
Dunnett, S. B., & Björklund, A. (1999) · Nature · doi:10.1038/399a032 · Cited by 537
Absolute requirement of GDNF for adult catecholaminergic neuron survival
Pascual, A., Hidalgo-Figueroa, M., Piruat, J. I., Pintado, C. O., Gómez-Díaz, R., & López-Barneo, J. (2008) · Nature Neuroscience · doi:10.1038/nn.2136 · Cited by 334
Viral vectors for gene delivery to the nervous system
Davidson, B. L., & Breakefield, X. O. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1104 · Cited by 321
Self-citationBilang-Bleuel, A., Revah, F., Colin, P., Locquet, I., Robert, J.-J., Mallet, J., & Horellou, P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8818 · Cited by 297
Metadata
- Authors
- Choi-Lundberg, D. L., Lin, Q., Chang, Y.-N., Chiang, Y. L., Hay, C. M., Mohajeri, H., Davidson, B. L., & Bohn, M. C.
- Venue
- Science
- Published
- 1997-02-07
- Volume
- 275
- Issue
- 5301
- Pages
- 838-841
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2150857721
- Cited by
- 625
- References
- 1
- FWCI
- 44.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Choi-Lundberg, D. L., Lin, Q., Chang, Y.-N., Chiang, Y. L., Hay, C. M., Mohajeri, H., Davidson, B. L., & Bohn, M. C. (1997). Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy. Science. https://doi.org/10.1126/science.275.5301.838
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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