The DOI matches its Crossref record.
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Abstract
Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria.
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Items 101–101 of 101
Forskolin Increases cAMP Levels and Enhances Recombinant Antibody Production in CHO Cell Cultures
Yoon, C., Kim, D., Lim, J. H., & Lee, G. M. (2020) · Biotechnology Journal · doi:10.1002/biot.202000264 · Cited by 13
Metadata
- Authors
- Yang, J., Liu, X., Bhalla, K., Kim, C. N., Ibrado, A. M., Cai, J., Peng, T.-I., Jones, D. P., & Wang, X.
- Venue
- Science
- Published
- 1997-02-21
- Volume
- 275
- Issue
- 5303
- Pages
- 1129-1132
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979995768
- Cited by
- 4,911
- References
- 0
- FWCI
- 141.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
