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Crystal Structure of Formate Dehydrogenase H: Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe 4 S 4 Cluster
Abstract
Formate dehydrogenase H from Escherichia coli contains selenocysteine (SeCys), molybdenum, two molybdopterin guanine dinucleotide (MGD) cofactors, and an Fe 4 S 4 cluster at the active site and catalyzes the two-electron oxidation of formate to carbon dioxide. The crystal structures of the oxidized [Mo(VI), Fe 4 S 4(ox) ] form of formate dehydrogenase H (with and without bound inhibitor) and the reduced [Mo(IV), Fe 4 S 4(red) ] form have been determined, revealing a four-domain αβ structure with the molybdenum directly coordinated to selenium and both MGD cofactors. These structures suggest a reaction mechanism that directly involves SeCys 140 and His 141 in proton abstraction and the molybdenum, molybdopterin, Lys 44 , and the Fe 4 S 4 cluster in electron transfer.
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Citations
Cites
A structure-based catalytic mechanism for the xanthine oxidase family of molybdenum enzymes
Huber, R., Hof, P., Duarte, R. O., Moura, J. J., Moura, I., Liu, M. Y., LeGall, J., Hille, R., Archer, M., & Romão, M. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.8846 · Cited by 242
NAD-binding domains of dehydrogenases
Lesk, A. M. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80010-7 · Cited by 239
Cited by
The mononuclear molybdenum enzymes
Hille, R., Hall, J., & Basu, P. (2014) · Chemical Reviews · doi:10.1021/cr400443z · Cited by 1,738
Reich, H. J., & Hondal, R. J. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00031 · Cited by 923
On the origin of biochemistry at an alkaline hydrothermal vent
Martin, W., & Russell, M. J. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1881 · Cited by 771
Reversible interconversion of carbon dioxide and formate by an electroactive enzyme
Reda, T., Plugge, C. M., Abram, N. J., & Hirst, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801290105 · Cited by 561
Richardson, D. J. (2000) · Microbiology · doi:10.1099/00221287-146-3-551 · Cited by 544
Metadata
- Authors
- Boyington, J. C., Gladyshev, V. N., Khangulov, S. V., Stadtman, T. C., & Sun, P. D.
- Venue
- Science
- Published
- 1997-02-28
- Volume
- 275
- Issue
- 5304
- Pages
- 1305-1308
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2101639848
- Cited by
- 593
- References
- 2
- FWCI
- 45.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boyington, J. C., Gladyshev, V. N., Khangulov, S. V., Stadtman, T. C., & Sun, P. D. (1997). Crystal Structure of Formate Dehydrogenase H: Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe 4 S 4 Cluster. Science. https://doi.org/10.1126/science.275.5304.1305
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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