The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway
Abstract
Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by a chronic state of immune hyperactivation in patients. Infection of human peripheral blood lymphocytes with HIV-1 in vitro resulted in increased interleukin-2 (IL-2) secretion in response to T cell activation via the CD3 and CD28 receptors. Expression of the HIV-1 transactivator Tat recapitulated this phenotype and was associated with increased IL-2 secretion in response to costimulation with CD3 plus CD28. IL-2 superinduction by Tat occurred at the transcriptional level, was mediated by the CD28-responsive element in the IL-2 promoter, and was exclusively dependent on the 29 amino acids encoded by the second exon of Tat.
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Citations
Cites
Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28
Fraser, J. D., Irving, B. A., Crabtree, G. R., & Weiss, A. (1991) · Science · doi:10.1126/science.1846244 · Cited by 641
Cited by
Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B., Hagos, E., Lampiris, H., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852
Jordan, A., Defechereux, P., & Verdin, E. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1726 · Cited by 467
Self-citationMultifaceted Activities of the HIV-1 Transactivator of Transcription, Tat
Jeang, K.-T., Xiao, H., & Rich, E. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28837 · Cited by 414
Herida, M., Mary-Krause, M., Kaphan, R., Cadranel, J., Poizot-Martin, I., Rabaud, C., Plaisance, N., Tissot-Dupont, H., Boue, F., Lang, J.-M., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.01.096 · Cited by 339
Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines
Kane, L. P., Andres, P. G., Howland, K. C., Abbas, A. K., & Weiss, A. (2001) · Nature Immunology · doi:10.1038/83144 · Cited by 316
Metadata
- Authors
- Ott, M., Emiliani, S., Van Lint, C., Herbein, G., Lovett, J., Chirmule, N., McCloskey, T., Pahwa, S., & Verdin, E.
- Venue
- Science
- Published
- 1997-03-07
- Volume
- 275
- Issue
- 5305
- Pages
- 1481-1485
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005133363
- Cited by
- 211
- References
- 1
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Ott, M., Emiliani, S., Van Lint, C., Herbein, G., Lovett, J., Chirmule, N., McCloskey, T., Pahwa, S., & Verdin, E. (1997). Immune Hyperactivation of HIV-1-Infected T Cells Mediated by Tat and the CD28 Pathway. Science. https://doi.org/10.1126/science.275.5305.1481
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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