The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis
Abstract
Prenylated proteins contain a covalently linked cholesterol intermediate near their carboxyl-termini. Maturation of most prenylated proteins involves proteolytic removal of the last three amino acids. Two genes in Saccharomyces cerevisiae , RCE1 and AFC1 , were identified that appear to be responsible for this processing. The Afc1 protein is a zinc protease that participates in the processing of yeast a -factor mating pheromone. The Rce1 protein contributes to the processing of both Ras protein and a -factor. Deletion of both AFC1 and RCE1 resulted in the loss of proteolytic processing of prenylated proteins. Disruption of RCE1 led to defects in Ras localization and signaling and suppressed the activated phenotype associated with the allele RAS2 val19 .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS
Schafer, W. R., & Rine, J. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.001233 · Cited by 377
Self-citation
Cited by
RAS Proteins and Their Regulators in Human Disease
Simanshu, D. K., Nissley, D. V., & McCormick, F. (2017) · Cell · doi:10.1016/j.cell.2017.06.009 · Cited by 1,943
Ras proteins: different signals from different locations
Hancock, J. F. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1105 · Cited by 756
Endomembrane Trafficking of Ras
Choy, E., Chiu, V. K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I. E., & Philips, M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80607-8 · Cited by 697
Targeting protein prenylation for cancer therapy
Berndt, N., Hamilton, A. D., & Sebti, S. M. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3151 · Cited by 614
Pendás, A. M., Zhou, Z., Cadiñanos, J., Freije, J. M. P., Wang, J., Hultenby, K., Astudillo, A., Wernerson, A., Rodríguez, F., Tryggvason, K., et al. (2002) · Nature Genetics · doi:10.1038/ng871 · Cited by 554
Metadata
- Authors
- Boyartchuk, V. L., Ashby, M. N., & Rine, J.
- Venue
- Science
- Published
- 1997-03-21
- Volume
- 275
- Issue
- 5307
- Pages
- 1796-1800
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1964489808
- Cited by
- 361
- References
- 1
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis. https://app.cochat.ai/papers/10.1126/science.275.5307.1796
- The paper
- Boyartchuk, V. L., Ashby, M. N., & Rine, J. (1997). Modulation of Ras and a-Factor Function by Carboxyl-Terminal Proteolysis. Science. https://doi.org/10.1126/science.275.5307.1796
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
