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Crystal Structure of the Nucleotide Exchange Factor GrpE Bound to the ATPase Domain of the Molecular Chaperone DnaK
Abstract
The crystal structure of the adenine nucleotide exchange factor GrpE in complex with the adenosine triphosphatase (ATPase) domain of Escherichia coli DnaK [heat shock protein 70 (Hsp70)] was determined at 2.8 angstrom resolution. A dimer of GrpE binds asymmetrically to a single molecule of DnaK. The structure of the nucleotide-free ATPase domain in complex with GrpE resembles closely that of the nucleotide-bound mammalian Hsp70 homolog, except for an outward rotation of one of the subdomains of the protein. This conformational change is not consistent with tight nucleotide binding. Two long α helices extend away from the GrpE dimer and suggest a role for GrpE in peptide release from DnaK.
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Cited by
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
Hartl, F. U., & Hayer-Hartl, M. (2002) · Science · doi:10.1126/science.1068408 · Cited by 3,347
Self-citationRosenzweig, R., Nillegoda, N. B., Mayer, M. P., & Bukau, B. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0133-3 · Cited by 1,285
Verghese, J., Abrams, J., Wang, Y., & Morano, K. A. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05018-11 · Cited by 575
Narberhaus, F. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.1.64-93.2002 · Cited by 538
Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate
Bertelsen, E. B., Chang, L., Gestwicki, J. E., & Zuiderweg, E. R. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903503106 · Cited by 454
Metadata
- Authors
- Harrison, C. J., Hayer-Hartl, M., Liberto, M. D., Hartl, F.-U., & Kuriyan, J.
- Venue
- Science
- Published
- 1997-04-18
- Volume
- 276
- Issue
- 5311
- Pages
- 431-435
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2107334607
- Cited by
- 497
- References
- 0
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Harrison, C. J., Hayer-Hartl, M., Liberto, M. D., Hartl, F.-U., & Kuriyan, J. (1997). Crystal Structure of the Nucleotide Exchange Factor GrpE Bound to the ATPase Domain of the Molecular Chaperone DnaK. Science. https://doi.org/10.1126/science.276.5311.431
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