The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Requirement of Drosophila NF1 for Activation of Adenylyl Cyclase by PACAP38-Like Neuropeptides
Abstract
The human neurofibromatosis type 1 (NF1) tumor suppressor protein functions as a Ras-specific guanosine triphosphatase–activating protein, but the identity of Ras- mediated pathways modulated by NF1 remains unknown. A study of Drosophila NF1 mutants revealed that NF1 is essential for the cellular response to the neuropeptide PACAP38 (pituitary adenylyl cyclase–activating polypeptide) at the neuromuscular junction. The peptide induced a 100-fold enhancement of potassium currents by activating the Ras-Raf and adenylyl cyclase–adenosine 3’,5’-monophosphate (cAMP) pathways. This response was eliminated in NF1 mutants. NF1 appears to regulate the rutabaga -encoded adenylyl cyclase rather than the Ras-Raf pathway. Moreover, the NF1 defect was rescued by the exposure of cells to pharmacological treatment that increased concentrations of cAMP.
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Cites
The neurofibromatosis type 1 gene encodes a protein related to GAP
Xu, G., O'Connell, P., Viskochil, D., Cawthon, R., Robertson, M., Culver, M., Dunn, D., Stevens, J., Gesteland, R., White, R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90024-9 · Cited by 1,095
Brannan, C. I., Perkins, A. S., Vogel, K. S., Ratner, N., Nordlund, M. L., Reid, S. W., Buchberg, A. M., Jenkins, N. A., Parada, L. F., & Copeland, N. G. (1994) · Genes & Development · doi:10.1101/gad.8.9.1019 · Cited by 641
Livingstone, M. S., Sziber, P. P., & Quinn, W. G. (1984) · Cell · doi:10.1016/0092-8674(84)90316-7 · Cited by 587
Cited by
NF1 Tumor Suppressor Gene Function
Cichowski, K., & Jacks, T. (2001) · Cell · doi:10.1016/s0092-8674(01)00245-8 · Cited by 601
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
Costa, R. M., Federov, N. B., Kogan, J. H., Murphy, G. G., Stern, J., Ohno, M., Kucherlapati, R., Jacks, T., & Silva, A. J. (2002) · Nature · doi:10.1038/nature711 · Cited by 585
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor
Ratner, N., & Miller, S. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3911 · Cited by 493
Neuropeptides and their precursors in the fruitfly, Drosophila melanogaster☆
Vanden Broeck, J. (2001) · Peptides · doi:10.1016/s0196-9781(00)00376-4 · Cited by 321
Insights into the pathogenesis of neurofibromatosis 1 vasculopathy
Hamilton, S., & Friedman, J. (2000) · Clinical Genetics · doi:10.1034/j.1399-0004.2000.580501.x · Cited by 280
Metadata
- Authors
- Guo, H.-F., The, I., Hannan, F., Bernards, A., & Zhong, Y.
- Venue
- Science
- Published
- 1997-05-02
- Volume
- 276
- Issue
- 5313
- Pages
- 795-798
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038561872
- Cited by
- 208
- References
- 3
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Requirement of Drosophila NF1 for Activation of Adenylyl Cyclase by PACAP38-Like Neuropeptides. https://app.cochat.ai/papers/10.1126/science.276.5313.795
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- Guo, H.-F., The, I., Hannan, F., Bernards, A., & Zhong, Y. (1997). Requirement of Drosophila NF1 for Activation of Adenylyl Cyclase by PACAP38-Like Neuropeptides. Science. https://doi.org/10.1126/science.276.5313.795
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