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Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers
Abstract
Titin, a giant filamentous polypeptide, is believed to play a fundamental role in maintaining sarcomeric structural integrity and developing what is known as passive force in muscle. Measurements of the force required to stretch a single molecule revealed that titin behaves as a highly nonlinear entropic spring. The molecule unfolds in a high-force transition beginning at 20 to 30 piconewtons and refolds in a low-force transition at ∼2.5 piconewtons. A fraction of the molecule (5 to 40 percent) remains permanently unfolded, behaving as a wormlike chain with a persistence length (a measure of the chain’s bending rigidity) of 20 angstroms. Force hysteresis arises from a difference between the unfolding and refolding kinetics of the molecule relative to the stretch and release rates in the experiments, respectively. Scaling the molecular data up to sarcomeric dimensions reproduced many features of the passive force versus extension curve of muscle fibers.
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Cited by
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Izrailev, S., Stepaniants, S., Isralewitz, B., Kosztin, D., Lu, H., Molnar, F., Wriggers, W., & Schulten, K. (1999) · Lecture Notes in Computational Science and Engineering · doi:10.1007/978-3-642-58360-5_2 · Cited by 451
Ribas-Arino, J., & Marx, D. (2012) · Chemical Reviews · doi:10.1021/cr200399q · Cited by 448
Differential expression of cardiac titin isoforms and modulation of cellular stiffness
Cazorla, O., Freiburg, A., Helmes, M., Centner, T., McNabb, M., Wu, Y., Trombitás, K., Labeit, S., & Granzier, H. (2000) · Circulation Research · doi:10.1161/01.res.86.1.59 · Cited by 418
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Metadata
- Authors
- Kellermayer, M. S. Z., Smith, S. B., Granzier, H. L., & Bustamante, C.
- Venue
- Science
- Published
- 1997-05-16
- Volume
- 276
- Issue
- 5315
- Pages
- 1112-1116
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2172039086
- Cited by
- 1,217
- References
- 0
- FWCI
- 44.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kellermayer, M. S. Z., Smith, S. B., Granzier, H. L., & Bustamante, C. (1997). Folding-Unfolding Transitions in Single Titin Molecules Characterized with Laser Tweezers. Science. https://doi.org/10.1126/science.276.5315.1112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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