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HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia
Open accessAbstract
In allogeneic bone marrow transplantation (allo-BMT), donor lymphocytes play a central therapeutic role in both graft-versus-leukemia (GvL) and immune reconstitution. However, their use is limited by the risk of severe graft-versus-host disease (GvHD). Eight patients who relapsed or developed Epstein-Barr virus–induced lymphoma after T cell–depleted BMT were then treated with donor lymphocytes transduced with the herpes simplex virus thymidine kinase (HSV-TK) suicide gene. The transduced lymphocytes survived for up to 12 months, resulting in antitumor activity in five patients. Three patients developed GvHD, which could be effectively controlled by ganciclovir-induced elimination of the transduced cells. These data show that genetic manipulation of donor lymphocytes may increase the efficacy and safety of allo-BMT and expand its application to a larger number of patients.
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Citations
Cited by
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Metadata
- Authors
- Bonini, C., Ferrari, G., Verzeletti, S., Servida, P., Zappone, E., Ruggieri, L., Ponzoni, M., Rossini, S., Mavilio, F., Traversari, C., & Bordignon, C.
- Venue
- Science
- Published
- 1997-06-13
- Volume
- 276
- Issue
- 5319
- Pages
- 1719-1724
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2112041130
- Cited by
- 1,161
- References
- 0
- FWCI
- 39.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia. https://app.cochat.ai/papers/10.1126/science.276.5319.1719
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- Bonini, C., Ferrari, G., Verzeletti, S., Servida, P., Zappone, E., Ruggieri, L., Ponzoni, M., Rossini, S., Mavilio, F., Traversari, C., & Bordignon, C. (1997). HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia. Science. https://doi.org/10.1126/science.276.5319.1719
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