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Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA
Abstract
More than 1% of the world's population is chronically infected with hepatitis C virus (HCV). HCV infection can result in acute hepatitis, chronic hepatitis, and cirrhosis, which is strongly associated with development of hepatocellular carcinoma. Genetic studies of HCV replication have been hampered by lack of a bona fide infectious molecular clone. Full-length functional clones of HCV complementary DNA were constructed. RNA transcripts from the clones were found to be infectious and to cause disease in chimpanzees after direct intrahepatic inoculation. This work defines the structure of a functional HCV genome RNA and proves that HCV alone is sufficient to cause disease.
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Citations
Cited by
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,854
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
Wakita, T., Pietschmann, T., Kato, T., Date, T., Miyamoto, M., Zhao, Z., Murthy, K., Habermann, A., Kräusslich, H.-G., Mizokami, M., et al. (2005) · Nature Medicine · doi:10.1038/nm1268 · Cited by 2,754
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection
Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K. K., Carret, C., Lassnig, C., et al. (2014) · Nature Medicine · doi:10.1038/nm.3424 · Cited by 313
Self-citationStructure and Function of the Membrane Anchor Domain of Hepatitis C Virus Nonstructural Protein 5A
Penin, F., Brass, V., Appel, N., Ramboarina, S., Montserret, R., Ficheux, D., Blum, H. E., Bartenschlager, R., & Moradpour, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404761200 · Cited by 301
Virus-host coevolution: common patterns of nucleotide motif usage in Flaviviridae and their hosts
Lobo, F. P., Mota, B. E. F., Pena, S. D. J., Azevedo, V., Macedo, A. M., Tauch, A., Machado, C. R., & Franco, G. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006282 · Cited by 191
Metadata
- Authors
- Kolykhalov, A. A., Agapov, E. V., Blight, K. J., Mihalik, K., Feinstone, S. M., & Rice, C. M.
- Venue
- Science
- Published
- 1997-07-25
- Volume
- 277
- Issue
- 5325
- Pages
- 570-574
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045562270
- Cited by
- 735
- References
- 0
- FWCI
- 22.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA. https://app.cochat.ai/papers/10.1126/science.277.5325.570
- The paper
- Kolykhalov, A. A., Agapov, E. V., Blight, K. J., Mihalik, K., Feinstone, S. M., & Rice, C. M. (1997). Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA. Science. https://doi.org/10.1126/science.277.5325.570
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
