The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Failure of Parturition in Mice Lacking the Prostaglandin F Receptor
Abstract
Mice lacking the gene encoding the receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of the lack of induction of oxytocin receptor (a proposed triggering event in parturition), and they did not show the normal decline of serum progesterone concentrations that precedes parturition. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and permitted successful delivery in the FP-deficient mice. These results indicate that parturition is initiated when prostaglandin F 2α interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis.
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“Multiple factors initiate parturition, including fetal cortisol, maternal drop in progesterone, oxytocin, prostaglandin F2α and other endocrine factors56–59.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [58]
Citations
Cites
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
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Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
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Structure and expression of a human oxytocin receptor
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Endocrine control of parturition
Thorburn, G. D., & Challis, J. R. G. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.863 · Cited by 426
Oxytocin Receptors: Triggers for Parturition and Lactation?
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Prostaglandin F2α identified as a Luteolytic Hormone in Sheep
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Uterine luteolytic hormone: a physiological role for prostaglandin F2alpha
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Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition
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Cited by
Sorted by citations
Prostaglandins and Inflammation
Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 4,035
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Cyclooxygenase in biology and disease
Dubois, R. N., Abramson, S. B., Crofford, L., Gupta, R., Simon, L. S., Putte, L., & Lipsky, P. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.12.1063 · Cited by 2,606
“In mice, the production of PGF2a by the fetal and/or uterine tissues signals the ovary to induce luteolysis (63), leading to a decline in maternal progesterone”
BackgroundProstanoid Receptors: Structures, Properties, and Functions
Narumiya, S., Sugimoto, Y., & Ushikubi, F. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1193 · Cited by 2,417
Self-citationCyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Simmons, D. L., Botting, R. M., & Hla, T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.3 · Cited by 1,718
“The action of PGF2 on the FP receptor of the corpus luteum induces luteolysis, which terminates progesterone production, and hence triggers parturition, for, in the absence of progesterone, the uterus becomes more sensitive to oxytocin (Sugimoto et al., 1997).”
Background
Metadata
- Authors
- Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., Hasumoto, K.-Y., Murata, T., Hirata, M., Ushikubi, F., Negishi, M., Ichikawa, A., & Narumiya, S.
- Affiliations
- Kyoto University (JP)
- Y. Sugimoto, A. Yamasaki, E. Segi, K. Tsuboi, M. Katsuyama, K. Hasumoto, M. Negishi, A. Ichikawa, Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan.
- Corresponding author
- Ichikawa, Atsushi
- ORCID
- Venue
- Science
- Published
- 1997-08
- Volume
- 277
- Issue
- 5326
- Pages
- 681-683
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2142980049
- Cited by
- 608
- References
- 16
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 12 · 2020: 24 · 2019: 19 · 2018: 18 · 2017: 12 · 2016: 17 · 2015: 17 · 2014: 21 · 2013: 15 · 2012: 11
- FWCI
- 85.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Reproductive Physiology in Livestock
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- childbirth, prostaglandin F2alpha, FP receptor, oxytocin receptor, luteolysis, progesterone, ovariectomy, luteal cells, pregnancy, knockout mice, estrous cycle
- MeSH terms
- Animals, Corpus Luteum, Female, Heterozygote, Homozygote, Labor, Obstetric, Male, Mice, Inbred C57BL, Ovariectomy, Oxytocin, Pregnancy, Progesterone, Receptors, Prostaglandin, Uterine Contraction, Uterus, Dinoprost, Receptors, Oxytocin, Gene Targeting, Mice
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