The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
LKLF: A Transcriptional Regulator of Single-Positive T Cell Quiescence and Survival
Abstract
Mature single-positive (SP) T lymphocytes enter a “resting” state in which they are proliferatively quiescent and relatively resistant to apoptosis. The molecular mechanisms regulating this quiescent phenotype were unknown. Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell activation. LKLF-deficient T cells produced by gene targeting had a spontaneously activated phenotype and died in the spleen and lymph nodes from Fas ligand–induced apoptosis. Thus, LKLF is required to program the quiescent state of SP T cells and to maintain their viability in the peripheral lymphoid organs and blood.
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Cites
Defective activation and survival of T cells lacking the Ets-1 transcription factor
Muthusamy, N., Barton, K., & Leiden, J. M. (1995) · Nature · doi:10.1038/377639a0 · Cited by 330
Self-citationCrossley, M., Whitelaw, E., Perkins, A., Williams, G., Fujiwara, Y., & Orkin, S. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1695 · Cited by 222
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Metadata
- Authors
- Kuo, C. T., Veselits, M. L., & Leiden, J. M.
- Venue
- Science
- Published
- 1997-09-26
- Volume
- 277
- Issue
- 5334
- Pages
- 1986-1990
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036455976
- Cited by
- 419
- References
- 2
- FWCI
- 6.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kuo, C. T., Veselits, M. L., & Leiden, J. M. (1997). LKLF: A Transcriptional Regulator of Single-Positive T Cell Quiescence and Survival. Science. https://doi.org/10.1126/science.277.5334.1986
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