The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Knockout-Transgenic Mouse Model of Sickle Cell Disease
Abstract
When transgenic mice that expressed human sickle hemoglobin were mated with mice having knockout mutations of the mouse α- and β-globin genes, animals were produced that synthesized only human hemoglobin in adult red blood cells. Similar to many human patients with sickle cell disease, the mice developed a severe hemolytic anemia and extensive organ pathology. Numerous sickled erythrocytes were observed in peripheral blood. Although chronically anemic, most animals survived for 2 to 9 months and were fertile. Drug and genetic therapies can now be tested in this mouse model of sickle cell disease.
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Cites
INGRAM, V. M. (1957) · Nature · doi:10.1038/180326a0 · Cited by 978
A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin
INGRAM, V. M. (1956) · Nature · doi:10.1038/178792a0 · Cited by 896
Hemoglobin S gelation and sickle cell disease
Eaton, W., & Hofrichter, J. (1987) · Blood · doi:10.1182/blood.v70.5.1245.1245 · Cited by 425
Three-dimensional reconstruction of the 14-filament fibers of hemoglobin S
Dykes, G. W., Crepeau, R. H., & Edelstein, S. J. (1979) · Journal of Molecular Biology · doi:10.1016/0022-2836(79)90434-0 · Cited by 186
Cited by
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
Hanna, J., Wernig, M., Markoulaki, S., Sun, C.-W., Meissner, A., Cassady, J. P., Beard, C., Brambrink, T., Wu, L.-C., Townes, T. M., et al. (2007) · Science · doi:10.1126/science.1152092 · Cited by 1,202
Self-citationCorrection of sickle cell disease in transgenic mouse models by gene therapy
Pawliuk, R., Westerman, K. A., Fabry, M. E., Payen, E., Tighe, R., Bouhassira, E. E., Acharya, S. A., Ellis, J., London, I. M., Eaves, C. J., et al. (2001) · Science · doi:10.1126/science.1065806 · Cited by 579
The hypercoagulable state in thalassemia
Eldor, A., & Rachmilewitz, E. A. (2002) · Blood · doi:10.1182/blood.v99.1.36 · Cited by 503
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Theurl, I., Hilgendorf, I., Nairz, M., Tymoszuk, P., Haschka, D., Asshoff, M., He, S., Gerhardt, L. M. S., Holderried, T. A. W., Seifert, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4146 · Cited by 412
Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease
Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221292098 · Cited by 391
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Metadata
- Authors
- Ryan, T. M., Ciavatta, D. J., & Townes, T. M.
- Venue
- Science
- Published
- 1997-10-31
- Volume
- 278
- Issue
- 5339
- Pages
- 873-876
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972406498
- Cited by
- 300
- References
- 4
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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