Cited by 359Muscle Physiology and DisordersProtein Tyrosine PhosphatasesDevelopmental Biology and Gene Regulation

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Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases

Bennett, Anton M., Tonks, Nicholas K.·1997·Science

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Abstract

The signal transduction pathway or pathways linking extracellular signals to myogenesis are poorly defined. Upon mitogen withdrawal from C2C12 myoblasts, the mitogen-activated protein kinase (MAPK) p42Erk2 is inactivated concomitant with up-regulation of muscle-specific genes. Overexpression of MAPK phosphatase-1 (MKP-1) inhibited p42Erk2 activity and was sufficient to relieve the inhibitory effects of mitogens on muscle-specific gene expression. Later during myogenesis, endogenous expression of MKP-1 decreased. MKP-1 overexpression during differentiation prevented myotube formation despite appropriate expression of myosin heavy chain. This indicates that muscle-specific gene expression is necessary but not sufficient to commit differentiated myocytes to myotubes and suggests a function for the MAPKs during the early and late stages of skeletal muscle differentiation.

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Untitled work
Drexler, H. (2002) · doi:10.1290/1071-2690(2002)038

Authors: Bennett, A. M., & Tonks, N. K.
Affiliations: Cold Spring Harbor Laboratory (US)
Corresponding author: Tonks, Nicholas K.
ORCID: Bennett, Anton M.
Tonks, Nicholas K.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-11-14
Volume: 278
Issue: 5341
Pages: 1288-1291
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.278.5341.1288
OpenAlex: W1975358464
Cited by: 359
References: 28
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 12 · 2017: 9 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 12 · 2012: 11
FWCI: 7.23
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: skeletal muscle differentiation, myogenesis, mitogen-activated protein kinase, MAPK phosphatase-1, MKP-1, C2C12 myoblasts, muscle-specific gene expression, myotube formation, signal transduction, myosin heavy chain
MeSH terms: Animals, Cell Differentiation, Cell Division, Cell Line, Cloning, Molecular, Culture Media, Mitogens, Muscle Proteins, Phosphoprotein Phosphatases, Phosphorylation, Recombinant Fusion Proteins, Tetracycline, Transcription, Genetic, Signal Transduction, Protein Tyrosine Phosphatases, Calcium-Calmodulin-Dependent Protein Kinases, Immediate-Early Proteins, Muscle, Skeletal, Gene Expression Regulation, Developmental, Cell Cycle Proteins, Cyclin D1, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, Mice, Dual Specificity Phosphatase 1, Protein Phosphatase 1

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Regulation of Distinct Stages of Skeletal Muscle Differentiation by Mitogen-Activated Protein Kinases

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