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Multistep Control of Pituitary Organogenesis
Abstract
Lhx3 and Lhx4 ( Gsh4 ), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps—first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.
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Cited by
Recent advances in central congenital hypothyroidism
Schoenmakers, N., Alatzoglou, K. S., Chatterjee, V. K., & Dattani, M. T. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0341 · Cited by 125
Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency
Pfäffle, R., & Klammt, J. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.014 · Cited by 115
The origins of the circumventricular organs
Kiecker, C. (2018) · Journal of Anatomy · doi:10.1111/joa.12771 · Cited by 92
Metadata
- Authors
- Sheng, H. Z., Moriyama, K., Yamashita, T., Li, H., Potter, S. S., Mahon, K. A., & Westphal, H.
- Venue
- Science
- Published
- 1997-12-05
- Volume
- 278
- Issue
- 5344
- Pages
- 1809-1812
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018270751
- Cited by
- 384
- References
- 0
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Multistep Control of Pituitary Organogenesis. https://app.cochat.ai/papers/10.1126/science.278.5344.1809
- The paper
- Sheng, H. Z., Moriyama, K., Yamashita, T., Li, H., Potter, S. S., Mahon, K. A., & Westphal, H. (1997). Multistep Control of Pituitary Organogenesis. Science. https://doi.org/10.1126/science.278.5344.1809
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
