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Spatial Buffering of Light-Evoked Potassium Increases by Retinal Müller (Glial) Cells
Open accessAbstract
Activity-dependent variations in extracellular potassium concentration in the central nervous system may be regulated, in part, by potassium spatial buffering currents in glial cells. The role of spatial buffering in the retina was assessed by measuring light-evoked potassium changes in amphibian eyecups. The amplitude of potassium increases in the vitreous humor was reduced to ∼10 percent by 50 micromolar barium, while potassium increases in the inner plexiform layer were largely unchanged. The decrease in the vitreal potassium response was accurately simulated with a numerical model of potassium current flow through Müller cells, the principal glial cells of the retina. Barium also substantially increased the input resistance of Müller cells and blocked the Müller cell-generated M-wave, indicating that barium blocks the potassium channels of Müller cells. Thus, after a light-evoked potassium increase within the retina, there is a substantial transfer of potassium from the retina to the vitreous humor by potassium current flow through Müller cells.
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Cites
Dietzel, I., Heinemann, U., Hofmeier, G., & Lux, H. D. (1980) · Experimental Brain Research · doi:10.1007/bf00236151 · Cited by 357
Cited by
Chen, Y., & Swanson, R. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200302000-00001 · Cited by 912
Neuronal activity triggers calcium waves in hippocampal astrocyte networks
Dani, J. W., Chernjavsky, A., & Smith, S. J. (1992) · Neuron · doi:10.1016/0896-6273(92)90271-e · Cited by 803
The Müller cell: a functional element of the retina
Newman, E., & Reichenbach, A. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10040-0 · Cited by 788
Self-citationPhysiological Roles of Aquaporin-4 in Brain
Nagelhus, E. A., & Ottersen, O. P. (2013) · Physiological Reviews · doi:10.1152/physrev.00011.2013 · Cited by 766
Müller Glial Cells in Retinal Disease
Bringmann, A., & Wiedemann, P. (2012) · Ophthalmologica · doi:10.1159/000328979 · Cited by 436
Metadata
- Authors
- Karwoski, C. J., Lu, H.-K., & Newman, E. A.
- Venue
- Science
- Published
- 1989-05-05
- Volume
- 244
- Issue
- 4904
- Pages
- 578-580
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080794145
- Cited by
- 215
- References
- 1
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Karwoski, C. J., Lu, H.-K., & Newman, E. A. (1989). Spatial Buffering of Light-Evoked Potassium Increases by Retinal Müller (Glial) Cells. Science. https://doi.org/10.1126/science.2785716
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
