The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Abstract
Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line–tropic human immunodeficiency virus–type 1 (HIV-1). A common polymorphism,SDF1-3′A, was identified in an evolutionarily conserved segment of the 3′ untranslated region of the SDF-1 structural gene transcript. In the homozygous state,SDF1-3′A/3′A delays the onset of acquired immunodeficiency syndrome (AIDS), according to a genetic association analysis of 2857 patients enrolled in five AIDS cohort studies. The recessive protective effect of SDF1-3′A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.
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Metadata
- Authors
- Winkler, C., Modi, W., Smith, M. W., Nelson, G. W., Wu, X., Carrington, M., Dean, M., Honjo, T., Tashiro, K., Yabe, D., Buchbinder, S., Vittinghoff, E., Goedert, J. J., O'Brien, T. R., Jacobson, L. P., Detels, R., Donfield, S., Willoughby, A., Gomperts, E., Vlahov, D., Phair, J., Study, A., (HGDS), H. G. A. D. S., (MACS), M. A. C. S., (MHCS), M. H. C. S., (SFCC), S. F. C. C., & O'Brien, S. J.
- Venue
- Science
- Published
- 1998-01-16
- Volume
- 279
- Issue
- 5349
- Pages
- 389-393
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2106915606
- Cited by
- 710
- References
- 37
- FWCI
- 23.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Winkler, C., Modi, W., Smith, M. W., Nelson, G. W., Wu, X., Carrington, M., Dean, M., Honjo, T., Tashiro, K., Yabe, D., Buchbinder, S., Vittinghoff, E., Goedert, J. J., O'Brien, T. R., Jacobson, L. P., Detels, R., Donfield, S., Willoughby, A., Gomperts, E., . . . O'Brien, S. J. (1998). Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant. Science. https://doi.org/10.1126/science.279.5349.389
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
