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A Distinctive Class of Integron in the Vibrio cholerae Genome
Abstract
The ability of bacteria to acquire and disseminate heterologous genes has been a major factor in the development of multiple drug resistance. A gene, intI4 , was identified that encodes a previously unknown integrase that is associated with a “gene-VCR” organization (VCRs are Vibrio cholerae repeated sequences), similar to that of the well-characterized antibiotic resistance integrons. The similarity was confirmed by IntI1-mediated recombination of a gene-VCR cassette into a class 1 integron. VCR cassettes are found in a number of Vibrio species including a strain of V. metschnikovii isolated in 1888, suggesting that this mechanism of heterologous gene acquisition predated the antibiotic era.
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Citations
Cited by
Lateral gene transfer and the nature of bacterial innovation
Ochman, H., Lawrence, J. G., & Groisman, E. A. (2000) · Nature · doi:10.1038/35012500 · Cited by 3,816
Molecular Mechanisms of Antibacterial Multidrug Resistance
Alekshun, M. N., & Levy, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.03.004 · Cited by 1,647
Integrons and Gene Cassettes in the Enterobacteriaceae
White, P. A., McIver, C. J., & Rawlinson, W. D. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.9.2658-2661.2001 · Cited by 466
Hochhut, B., Lotfi, Y., Mazel, D., Faruque, S. M., Woodgate, R., & Waldor, M. K. (2001) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.45.11.2991-3000.2001 · Cited by 318
Self-citationBass, L., Liebert, C. A., Lee, M. D., Summers, A. O., White, D. G., Thayer, S. G., & Maurer, J. J. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.12.2925 · Cited by 293
Metadata
- Authors
- Mazel, D., Dychinco, B., Webb, V. A., & Davies, J.
- Venue
- Science
- Published
- 1998-04-24
- Volume
- 280
- Issue
- 5363
- Pages
- 605-608
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997873483
- Cited by
- 403
- References
- 0
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mazel, D., Dychinco, B., Webb, V. A., & Davies, J. (1998). A Distinctive Class of Integron in the Vibrio cholerae Genome. Science. https://doi.org/10.1126/science.280.5363.605
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