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Redox-Coupled Crystal Structural Changes in Bovine Heart Cytochrome c Oxidase
Abstract
Crystal structures of bovine heart cytochrome c oxidase in the fully oxidized, fully reduced, azide-bound, and carbon monoxide–bound states were determined at 2.30, 2.35, 2.9, and 2.8 angstrom resolution, respectively. An aspartate residue apart from the O 2 reduction site exchanges its effective accessibility to the matrix aqueous phase for one to the cytosolic phase concomitantly with a significant decrease in the pK of its carboxyl group, on reduction of the metal sites. The movement indicates the aspartate as the proton pumping site. A tyrosine acidified by a covalently linked imidazole nitrogen is a possible proton donor for the O 2 reduction by the enzyme.
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Citations
Cited by
Infrared spectroscopy of proteins
Barth, A. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.06.004 · Cited by 5,129
“The results are in line with the proposed role of this residue in proton pumping by mammalian oxidases [407].”
ResultStructure and chemistry of cytochrome p450
Denisov, I. G., Makris, T. M., Sligar, S. G., & Schlichting, I. (2005) · Chemical Reviews · doi:10.1021/cr0307143 · Cited by 2,106
Proton-coupled electron transfer
Huynh, M. H. V., & Meyer, T. J. (2007) · Chemical Reviews · doi:10.1021/cr0500030 · Cited by 1,659
Oxidative Phosphorylation at the fin de siècle
Saraste, M. (1999) · Science · doi:10.1126/science.283.5407.1488 · Cited by 1,313
Gray, H. B., & Winkler, J. R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408029102 · Cited by 855
Metadata
- Authors
- Yoshikawa, S., Shinzawa-Itoh, K., Nakashima, R., Yaono, R., Yamashita, E., Inoue, N., Yao, M., Fei, M. J., Libeu, C. P., Mizushima, T., Yamaguchi, H., Tomizaki, T., & Tsukihara, T.
- Venue
- Science
- Published
- 1998-06-12
- Volume
- 280
- Issue
- 5370
- Pages
- 1723-1729
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2138360835
- Cited by
- 1,039
- References
- 0
- FWCI
- 56.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yoshikawa, S., Shinzawa-Itoh, K., Nakashima, R., Yaono, R., Yamashita, E., Inoue, N., Yao, M., Fei, M. J., Libeu, C. P., Mizushima, T., Yamaguchi, H., Tomizaki, T., & Tsukihara, T. (1998). Redox-Coupled Crystal Structural Changes in Bovine Heart Cytochrome c Oxidase. Science. https://doi.org/10.1126/science.280.5370.1723
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