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Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell
Abstract
Activation of nonreceptor protein tyrosine kinases (PTKs) is essential for T cell receptor (TCR) responsiveness; however, the function of individual PTK substrates is often uncertain. A mutant T cell line was isolated that lacked expression of SLP-76 (SH2 domain–containing leukocyte protein of 76 kilodaltons), a hematopoietically expressed adaptor protein and PTK substrate. SLP-76 was not required for TCR-induced tyrosine phosphorylation of most proteins, but was required for optimal tyrosine phosphorylation and activation of phospholipase C-γ1 (PLC-γ1), as well as Ras pathway activation. TCR-inducible gene expression was dependent on SLP-76. Thus, coupling of TCR-regulated PTKs to downstream signaling pathways requires SLP-76.
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Bunnell, S. C., Hong, D. I., Kardon, J. R., Yamazaki, T., McGlade, C. J., Barr, V. A., & Samelson, L. E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203043 · Cited by 632
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Metadata
- Authors
- Yablonski, D., Kuhne, M. R., Kadlecek, T., & Weiss, A.
- Venue
- Science
- Published
- 1998-07-17
- Volume
- 281
- Issue
- 5375
- Pages
- 413-416
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077648546
- Cited by
- 412
- References
- 0
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell. https://app.cochat.ai/papers/10.1126/science.281.5375.413
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- Yablonski, D., Kuhne, M. R., Kadlecek, T., & Weiss, A. (1998). Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell. Science. https://doi.org/10.1126/science.281.5375.413
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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