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Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development
Abstract
The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain–containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76–deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre–T cell receptors into distal biochemical events.
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Cited by
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Wienands, J., Schweikert, J., Wollscheid, B., Jumaa, H., Nielsen, P. J., & Reth, M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.4.791 · Cited by 271
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Metadata
- Authors
- Clements, J. L., Yang, B., Ross-Barta, S. E., Eliason, S. L., Hrstka, R. F., Williamson, R. A., & Koretzky, G. A.
- Venue
- Science
- Published
- 1998-07-17
- Volume
- 281
- Issue
- 5375
- Pages
- 416-419
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002943653
- Cited by
- 400
- References
- 0
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Clements, J. L., Yang, B., Ross-Barta, S. E., Eliason, S. L., Hrstka, R. F., Williamson, R. A., & Koretzky, G. A. (1998). Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development. Science. https://doi.org/10.1126/science.281.5375.416
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
