All You Need Is RNA
Abstract
What does it take to string amino acids together to form a protein? This essential process of life, synthesis of peptide bonds, can be accomplished by naked RNA molecules, as Schimmel and Alexander explain in their Perspective. This notion, bolstered by the results of Nitta et al. in this week9s issue, paints a picture of how the first proteins may have been synthesized in an ancient world where RNA molecules were the precursors of life.
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The rRNAs are folded into highly compact, precise three-dimensional structures to form the core of the ribosome.
“The rRNAs are folded into highly compact, precise three-dimensional structures to form the core of the ribosome, whereas the r-proteins are generally located on the surface, where they fill the gaps and crevices of the folded RNA and act to fold and stabilize the core [95].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [95]
The r-proteins are generally located on the surface of the ribosome, where they fill gaps and crevices of the folded RNA and act to fold and stabilize the core.
“The rRNAs are folded into highly compact, precise three-dimensional structures to form the core of the ribosome, whereas the r-proteins are generally located on the surface, where they fill the gaps and crevices of the folded RNA and act to fold and stabilize the core [95].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [95]
Cites
Peptide bond formation by in vitro selected ribozymes
Zhang, B., & Cech, T. R. (1997) · Nature · doi:10.1038/36375 · Cited by 299 · see citing works
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Chatterjee, S., & Yadav, S. (2019) · Life · doi:10.3390/life9010025 · Cited by 80 · see citing works
“peptidyl transferase center of the large ribosomal subunit [87, 88].”
Background
- Authors
- Schimmel, P., & Alexander, R.
- Affiliations
- Scripps Research Institute (US)
- Venue
- Science
- Published
- 1998-07-31
- Volume
- 281
- Issue
- 5377
- Pages
- 658-659
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1677418304
- Cited by
- 14
- References
- 1
- Citations by year
- 2023: 1 · 2019: 1 · 2018: 1 · 2012: 1
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- peptide bond formation, origin of life, ribozymes
- MeSH terms
- Algorithms, Anticodon, Codon, Escherichia coli, Nucleic Acid Conformation, Peptide Biosynthesis, Peptidyl Transferases, Ribosomes, RNA, Bacterial, RNA, Ribosomal, 23S, RNA, Transfer, Amino Acyl, Templates, Genetic
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