The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion
Abstract
The small guanosine triphosphatases (GTPases) Cdc42 and Rac1 regulate E-cadherin–mediated cell-cell adhesion. IQGAP1, a target of Cdc42 and Rac1, was localized with E-cadherin and β-catenin at sites of cell-cell contact in mouse L fibroblasts expressing E-cadherin (EL cells), and interacted with E-cadherin and β-catenin both in vivo and in vitro. IQGAP1 induced the dissociation of α-catenin from a cadherin-catenin complex in vitro and in vivo. Overexpression of IQGAP1 in EL cells, but not in L cells expressing an E-cadherin–α-catenin chimeric protein, resulted in a decrease in E-cadherin–mediated cell-cell adhesive activity. Thus, IQGAP1, acting downstream of Cdc42 and Rac1, appears to regulate cell-cell adhesion through the cadherin-catenin pathway.
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Nobes, C. D., & Hall, A. (1995) · Cell · doi:10.1016/0092-8674(95)90370-4 · Cited by 4,412
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,652
Morphogenetic roles of classic cadherins
Takeichi, M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80102-2 · Cited by 1,450
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
Coso, O. A., Chiariello, M., Yu, J.-C., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Silvio Gutkind, J. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,397
Ozawa, M., Baribault, H., & Kemler, R. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03563.x · Cited by 1,396
An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1
Olson, M. F., Ashworth, A., & Hall, A. (1995) · Science · doi:10.1126/science.7652575 · Cited by 1,146
Drubin, D. G., & Nelson, W. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81278-7 · Cited by 1,025
Kozma, R., Ahmed, S., Best, A., & Lim, L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.1942 · Cited by 1,021
Braga, V. M. M., Machesky, L. M., Hall, A., & Hotchin, N. A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.6.1421 · Cited by 769
Hinck, L., Näthke, I. S., Papkoff, J., & Nelson, W. J. (1994) · The Journal of cell biology · doi:10.1083/jcb.125.6.1327 · Cited by 628
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Cavallaro, U., & Christofori, G. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1276 · Cited by 1,311
Perez-Moreno, M., Jamora, C., & Fuchs, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00108-9 · Cited by 721
Rho-family GTPases in cadherin-mediated cell — cell adhesion
Fukata, M., & Kaibuchi, K. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35103068 · Cited by 438
Self-citationEhrlich, J. S., Hansen, M. D. H., & Nelson, W. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00216-2 · Cited by 358
Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex
Jossin, Y., & Cooper, J. A. (2011) · Nature Neuroscience · doi:10.1038/nn.2816 · Cited by 332
Metadata
- Authors
- Kuroda, S., Fukata, M., Nakagawa, M., Fujii, K., Nakamura, T., Ookubo, T., Izawa, I., Nagase, T., Nomura, N., Tani, H., Shoji, I., Matsuura, Y., Yonehara, S., & Kaibuchi, K.
- Venue
- Science
- Published
- 1998-08-07
- Volume
- 281
- Issue
- 5378
- Pages
- 832-835
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2124713665
- Cited by
- 499
- References
- 24
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Kuroda, S., Fukata, M., Nakagawa, M., Fujii, K., Nakamura, T., Ookubo, T., Izawa, I., Nagase, T., Nomura, N., Tani, H., Shoji, I., Matsuura, Y., Yonehara, S., & Kaibuchi, K. (1998). Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell Adhesion. Science. https://doi.org/10.1126/science.281.5378.832
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
