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Segregation of Transcription and Replication Sites Into Higher Order Domains
Abstract
Microscopy shows that individual sites of DNA replication and transcription of mammalian nuclei segregate into sets of roughly 22 and 16 higher order domains, respectively. Each domain set displayed a distinct network-like appearance, including regions of individual domains and interdigitation of domains between the two networks. These data support a dynamic mosaic model for the higher order arrangement of genomic function inside the cell nuclei.
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Cited by
Ishov, A. M., Sotnikov, A. G., Negorev, D., Vladimirova, O. V., Neff, N., Kamitani, T., Yeh, E. T. H., Strauss, J. F., & Maul, G. G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.221 · Cited by 832
Cellular responses to hyperthermia (40–46°C): Cell killing and molecular events
Roti Roti, J. L. (2008) · International Journal of Hyperthermia · doi:10.1080/02656730701769841 · Cited by 573
Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place
Kotsantis, P., Petermann, E., & Boulton, S. J. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1461 · Cited by 416
DNA Replication and Oncogene-Induced Replicative Stress
Hills, S. A., & Diffley, J. F. X. (2014) · Current Biology · doi:10.1016/j.cub.2014.04.012 · Cited by 381
DNA damage and transcription stress
Milano, L., Gautam, A., & Caldecott, K. W. (2024) · Molecular Cell · doi:10.1016/j.molcel.2023.11.014 · Cited by 88
Metadata
- Authors
- Wei, X., Samarabandu, J., Devdhar, R. S., Siegel, A. J., Acharya, R., & Berezney, R.
- Venue
- Science
- Published
- 1998-09-04
- Volume
- 281
- Issue
- 5382
- Pages
- 1502-1505
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006048118
- Cited by
- 276
- References
- 0
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wei, X., Samarabandu, J., Devdhar, R. S., Siegel, A. J., Acharya, R., & Berezney, R. (1998). Segregation of Transcription and Replication Sites Into Higher Order Domains. Science. https://doi.org/10.1126/science.281.5382.1502
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
