The DOI matches its Crossref record.
Fertilization Defects in Sperm from Mice Lacking Fertilin β
Abstract
Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm. Sperm from mice lacking fertilin β were shown to be deficient in sperm-egg membrane adhesion, sperm-egg fusion, migration from the uterus into the oviduct, and binding to the egg zona pellucida. Egg activation was unaffected. The results are consistent with a direct role of fertilin in sperm-egg plasma membrane interaction. Fertilin could also have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.
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Cited by
EDWARDS, D., HANDSLEY, M., & PENNINGTON, C. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.001 · Cited by 1,161
Genetic dissection of mammalian fertility pathways
Matzuk, M. M., & Lamb, D. J. (2002) · Nature Cell Biology · doi:10.1038/ncb-nm-fertilitys41 · Cited by 579
A profile of fertilization in mammals
Wassarman, P. M., Jovine, L., & Litscher, E. S. (2001) · Nature Cell Biology · doi:10.1038/35055178 · Cited by 393
The ADAMs family: Coordinators of nervous system development, plasticity and repair
Yang, P., Baker, K. A., & Hagg, T. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.05.001 · Cited by 116
New insights into the molecular mechanisms of sperm-egg interaction
Nixon, B., Aitken, R. J., & McLaughlin, E. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6552-x · Cited by 103
Metadata
- Authors
- Cho, C., O'Dell Bunch, D., Faure, J.-E., Goulding, E. H., Eddy, E. M., Primakoff, P., & Myles, D. G.
- Venue
- Science
- Published
- 1998-09-18
- Volume
- 281
- Issue
- 5384
- Pages
- 1857-1859
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085077505
- Cited by
- 499
- References
- 0
- FWCI
- 30.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cho, C., O'Dell Bunch, D., Faure, J.-E., Goulding, E. H., Eddy, E. M., Primakoff, P., & Myles, D. G. (1998). Fertilization Defects in Sperm from Mice Lacking Fertilin β. Science. https://doi.org/10.1126/science.281.5384.1857
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