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Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis
Abstract
p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.
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Citations
Cited by
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Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315
TNF-mediated inflammatory disease
Bradley, Jr. (2008) · The Journal of Pathology · doi:10.1002/path.2287 · Cited by 2,094
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
Chipuk, J. E., Kuwana, T., Bouchier-Hayes, L., Droin, N. M., Newmeyer, D. D., Schuler, M., & Green, D. R. (2004) · Science · doi:10.1126/science.1092734 · Cited by 2,108
The p53 pathway: positive and negative feedback loops
Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967
Metadata
- Authors
- Bennett, M., Macdonald, K., Chan, S.-W., Luzio, J. P., Simari, R., & Weissberg, P.
- Venue
- Science
- Published
- 1998-10-09
- Volume
- 282
- Issue
- 5387
- Pages
- 290-293
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2168084973
- Cited by
- 754
- References
- 0
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bennett, M., Macdonald, K., Chan, S.-W., Luzio, J. P., Simari, R., & Weissberg, P. (1998). Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis. Science. https://doi.org/10.1126/science.282.5387.290
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
