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An Integrated Nanoliter DNA Analysis Device
Abstract
A device was developed that uses microfabricated fluidic channels, heaters, temperature sensors, and fluorescence detectors to analyze nanoliter-size DNA samples. The device is capable of measuring aqueous reagent and DNA-containing solutions, mixing the solutions together, amplifying or digesting the DNA to form discrete products, and separating and detecting those products. No external lenses, heaters, or mechanical pumps are necessary for complete sample processing and analysis. Because all of the components are made using conventional photolithographic production techniques, they operate as a single closed system. The components have the potential for assembly into complex, low-power, integrated analysis systems at low unit cost. The availability of portable, reliable instruments may facilitate the use of DNA analysis in applications such as rapid medical diagnostics and point-of-use agricultural testing.
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Citations
Cited by
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Stroock, A. D., Dertinger, S. K. W., Ajdari, A., Mezić, I., Stone, H. A., & Whitesides, G. M. (2002) · Science · doi:10.1126/science.1066238 · Cited by 3,435
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Lewis, J. A. (2006) · Advanced Functional Materials · doi:10.1002/adfm.200600434 · Cited by 1,740
Adaptive liquid microlenses activated by stimuli-responsive hydrogels
Dong, L., Agarwal, A. K., Beebe, D. J., & Jiang, H. (2006) · Nature · doi:10.1038/nature05024 · Cited by 1,051
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693
Metadata
- Authors
- Burns, M. A., Johnson, B. N., Brahmasandra, S. N., Handique, K., Webster, J. R., Krishnan, M., Sammarco, T. S., Man, P. M., Jones, D., Heldsinger, D., Mastrangelo, C. H., & Burke, D. T.
- Venue
- Science
- Published
- 1998-10-16
- Volume
- 282
- Issue
- 5388
- Pages
- 484-487
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148927531
- Cited by
- 1,299
- References
- 0
- FWCI
- 47.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Burns, M. A., Johnson, B. N., Brahmasandra, S. N., Handique, K., Webster, J. R., Krishnan, M., Sammarco, T. S., Man, P. M., Jones, D., Heldsinger, D., Mastrangelo, C. H., & Burke, D. T. (1998). An Integrated Nanoliter DNA Analysis Device. Science. https://doi.org/10.1126/science.282.5388.484
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
