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Dual Requirement for Gephyrin in Glycine Receptor Clustering and Molybdoenzyme Activity
Abstract
Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Molecular cloning revealed the similarity of gephyrin to prokaryotic and invertebrate proteins essential for synthesizing a cofactor required for activity of molybdoenzymes. Gene targeting in mice showed that gephyrin is required both for synaptic clustering of glycine receptors in spinal cord and for molybdoenzyme activity in nonneural tissues. The mutant phenotype resembled that of humans with hereditary molybdenum cofactor deficiency and hyperekplexia (a failure of inhibitory neurotransmission), suggesting that gephyrin function may be impaired in both diseases.
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Cited by
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Welch, J. M., Lu, J., Rodriguiz, R. M., Trotta, N. C., Peca, J., Ding, J.-D., Feliciano, C., Chen, M., Adams, J. P., Luo, J., et al. (2007) · Nature · doi:10.1038/nature06104 · Cited by 852
Self-citationImmunocytochemical analysis of the mouse retina
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Metadata
- Authors
- Feng, G., Tintrup, H., Kirsch, J., Nichol, M. C., Kuhse, J., Betz, H., & Sanes, J. R.
- Venue
- Science
- Published
- 1998-11-13
- Volume
- 282
- Issue
- 5392
- Pages
- 1321-1324
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985620346
- Cited by
- 438
- References
- 0
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Feng, G., Tintrup, H., Kirsch, J., Nichol, M. C., Kuhse, J., Betz, H., & Sanes, J. R. (1998). Dual Requirement for Gephyrin in Glycine Receptor Clustering and Molybdoenzyme Activity. Science. https://doi.org/10.1126/science.282.5392.1321
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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