The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Single-Molecule Enzymatic Dynamics
Abstract
Enzymatic turnovers of single cholesterol oxidase molecules were observed in real time by monitoring the emission from the enzyme's fluorescent active site, flavin adenine dinucleotide (FAD). Statistical analyses of single-molecule trajectories revealed a significant and slow fluctuation in the rate of cholesterol oxidation by FAD. The static disorder and dynamic disorder of reaction rates, which are essentially indistinguishable in ensemble-averaged experiments, were determined separately by the real-time single-molecule approach. A molecular memory phenomenon, in which an enzymatic turnover was not independent of its previous turnovers because of a slow fluctuation of protein conformation, was evidenced by spontaneous spectral fluctuation of FAD.
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Cites
Direct observation of single kinesin molecules moving along microtubules
Vale, R. D., Funatsu, T., Pierce, D. W., Romberg, L., Harada, Y., & Yanagida, T. (1996) · Nature · doi:10.1038/380451a0 · Cited by 711
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Lu, Y., & Chen, W. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15325d · Cited by 1,152
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Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics
Iversen, L., Tu, H.-L., Lin, W.-C., Christensen, S. M., Abel, S. M., Iwig, J., Wu, H.-J., Gureasko, J., Rhodes, C., Petit, R. S., et al. (2014) · Science · doi:10.1126/science.1250373 · Cited by 154
Spin-Polarized Photon Emission by Resonant Multipolar Nanoantennas
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Metadata
- Authors
- Lu, H. P.
- Venue
- Science
- Published
- 1998-12-04
- Volume
- 282
- Issue
- 5395
- Pages
- 1877-1882
- ISSN
- 0036-8075 (ISSN-L)
- OpenAlex
- W2142337964
- Cited by
- 1,470
- References
- 1
- FWCI
- 32.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
