The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
p53-Independent Role of MDM2 in TGF-β1 Resistance
Abstract
Transforming growth factor–β (TGF-β) inhibits cell proliferation, and acquisition of TGF-β resistance has been linked to tumorigenesis. A genetic screen was performed to identify complementary DNAs that abrogated TGF-β sensitivity in mink lung epithelial cells. Ectopic expression of murine double minute 2 rescued TGF-β–induced growth arrest in a p53-independent manner by interference with retinoblastoma susceptibility gene product (Rb)/E2F function. In human breast tumor cells, increased MDM2 expression levels correlated with TGF-β resistance. Thus, MDM2 may confer TGF-β resistance in a subset of tumors and may promote tumorigenesis by interference with two independent tumor suppressors, p53 and Rb.
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Citations
Cites
Overexpression of the MDM2 Oncogene in Leukemia and Lymphoma
Watanabe, T., Ichikawa, A., Saito, H., & Hotta, T. (1996) · Leukemia & Lymphoma · doi:10.3109/10428199609093436 · Cited by 80
Günther, T., Schneider-Stock, R., Ryš, J., Niezabitowski, A., & Roessner, A. (1997) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf01240122 · Cited by 28
Cited by
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
Massagué, J., Blain, S. W., & Lo, R. S. (2000) · Cell · doi:10.1016/s0092-8674(00)00121-5 · Cited by 2,385
twist is a potential oncogene that inhibits apoptosis
Maestro, R., Tos, A. P. D., Hamamori, Y., Krasnokutsky, S., Sartorelli, V., Kedes, L., Doglioni, C., Beach, D. H., & Hannon, G. J. (1999) · Genes & Development · doi:10.1101/gad.13.17.2207 · Cited by 516
Self-citationWang, W., Chen, J. X., Liao, R., Deng, Q., Zhou, J. J., Huang, S., & Sun, P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3389-3403.2002 · Cited by 376
Self-citationMDM2 interacts with MDMX through their RING finger domains
Tanimura, S., Ohtsuka, S., Mitsui, K., Shirouzu, K., Yoshimura, A., & Ohtsubo, M. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00254-9 · Cited by 324
PRAK Is Essential for ras-Induced Senescence and Tumor Suppression
Sun, P., Yoshizuka, N., New, L., Moser, B. A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., et al. (2007) · Cell · doi:10.1016/j.cell.2006.11.050 · Cited by 321
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Metadata
- Authors
- Sun, P., Dong, P., Dai, K., Hannon, G. J., & Beach, D.
- Venue
- Science
- Published
- 1998-12-18
- Volume
- 282
- Issue
- 5397
- Pages
- 2270-2272
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982420043
- Cited by
- 195
- References
- 2
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sun, P., Dong, P., Dai, K., Hannon, G. J., & Beach, D. (1998). p53-Independent Role of MDM2 in TGF-β1 Resistance. Science. https://doi.org/10.1126/science.282.5397.2270
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