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Tandem Array of Human Visual Pigment Genes at Xq28
Abstract
Unequal crossing-over within a head-to-tail tandem array of the homologous red and green visual pigment genes has been proposed to explain the observed variation in green-pigment gene number among individuals and the prevalence of red-green fusion genes among color-blind subjects. This model was tested by probing the structure of the red and green pigment loci with long-range physical mapping techniques. The loci were found to constitute a gene array with an approximately 39-kilobase repeat length. The position of the red pigment gene at the 5′ edge of the array explains its lack of variation in copy number. Restriction maps of the array in four individuals who differ in gene number are consistent with a head-to-tail configuration of the genes. These results provide physical evidence in support of the model and help to explain the high incidence of color blindness in the human population.
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OPN1LW and OPN1MW are arranged in a tandem array.
“OPN1LW and OPN1MW are arranged in a tandem array”
From The genetics of normal and defective color vision (2011) · cites this paper as Vollrath, Nathans & Davis, 1988
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Cited by
Sorted by citations
The genetics of normal and defective color vision
Neitz, J., & Neitz, M. (2011) · Vision Research · doi:10.1016/j.visres.2010.12.002 · Cited by 377
McBee, J. K., Palczewski, K., Baehr, W., & Pepperberg, D. R. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00002-7 · Cited by 366
Evolution of colour vision in vertebrates
Bowmaker, J. K. (1998) · Eye · doi:10.1038/eye.1998.143 · Cited by 239
MOLECULAR GENETICS OF HUMAN VISUAL PIGMENTS
Nathans, J., Merbs, S. L., Sung, C.-H., Weitz, C. J., & Wang, Y. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.002155 · Cited by 185
Self-citation
Metadata
- Authors
- Vollrath, D., Nathans, J., & Davis, R. W.
- Affiliations
- Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305.
- Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
- Venue
- Science
- Published
- 1988-06-17
- Volume
- 240
- Issue
- 4859
- Pages
- 1669-1672
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 127
- References
- 0
- Language
- en
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