The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
Abstract
The Ca 2+ -activated protein phosphatase calcineurin induces apoptosis, but the mechanism is unknown. Calcineurin was found to dephosphorylate BAD, a pro-apoptotic member of the Bcl-2 family, thus enhancing BAD heterodimerization with Bcl-x L and promoting apoptosis. The Ca 2+ -induced dephosphorylation of BAD correlated with its dissociation from 14-3-3 in the cytosol and translocation to mitochondria where Bcl-x L resides. In hippocampal neurons, l -glutamate, an inducer of Ca 2+ influx and calcineurin activation, triggered mitochondrial targeting of BAD and apoptosis, which were both suppressible by coexpression of a dominant-inhibitory mutant of calcineurin or pharmacological inhibitors of this phosphatase. Thus, a Ca 2+ -inducible mechanism for apoptosis induction operates by regulating BAD phosphorylation and localization in cells.
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Cites
Ethell, I. M., & Yamaguchi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.3.575 · Cited by 209
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Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
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Redza-Dutordoir, M., & Averill-Bates, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.012 · Cited by 3,731
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
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Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103
Self-citation(2001) · PubMed · Cited by 2,381
Metadata
- Authors
- Wang, H.-G., Pathan, N., Ethell, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., & Reed, J. C.
- Venue
- Science
- Published
- 1999-04-09
- Volume
- 284
- Issue
- 5412
- Pages
- 339-343
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978559408
- Cited by
- 1,132
- References
- 1
- FWCI
- 28.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, H.-G., Pathan, N., Ethell, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., & Reed, J. C. (1999). Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD. Science. https://doi.org/10.1126/science.284.5412.339
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
