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Polymersomes: Tough Vesicles Made from Diblock Copolymers
Abstract
Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO 40 -EE 37 ), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements, but the giant polymersomes proved to be almost an order of magnitude tougher and sustained far greater areal strain before rupture. The polymersome membrane was also at least 10 times less permeable to water than common phospholipid bilayers. The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry.
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Citations
Cited by
Blanazs, A., Armes, S. P., & Ryan, A. J. (2009) · Macromolecular Rapid Communications · doi:10.1002/marc.200800713 · Cited by 1,500
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270
On the origins of morphological complexity in block copolymer surfactants
Jain, S., & Bates, F. S. (2003) · Science · doi:10.1126/science.1082193 · Cited by 1,217
Self-citationStimuli-Responsive Polymersomes for Programmed Drug Delivery
Meng, F., Zhong, Z., & Feijen, J. (2009) · Biomacromolecules · doi:10.1021/bm801127d · Cited by 1,122
Block Copolymer Assembly via Kinetic Control
Cui, H., Chen, Z., Zhong, S., Wooley, K. L., & Pochan, D. J. (2007) · Science · doi:10.1126/science.1141768 · Cited by 1,049
Metadata
- Authors
- Discher, B. M., Won, Y.-Y., Ege, D. S., Lee, J. C.-M., Bates, F. S., Discher, D. E., & Hammer, D. A.
- Venue
- Science
- Published
- 1999-05-14
- Volume
- 284
- Issue
- 5417
- Pages
- 1143-1146
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045678504
- Cited by
- 2,512
- References
- 0
- FWCI
- 32.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Discher, B. M., Won, Y.-Y., Ege, D. S., Lee, J. C.-M., Bates, F. S., Discher, D. E., & Hammer, D. A. (1999). Polymersomes: Tough Vesicles Made from Diblock Copolymers. Science. https://doi.org/10.1126/science.284.5417.1143
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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