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Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells
Abstract
Glutamic acid decarboxylase (GAD) is a pancreatic β cell autoantigen in humans and nonobese diabetic (NOD) mice. β Cell–specific suppression of GAD expression in two lines of antisense GAD transgenic NOD mice prevented autoimmune diabetes, whereas persistent GAD expression in the β cells in the other four lines of antisense GAD transgenic NOD mice resulted in diabetes, similar to that seen in transgene-negative NOD mice. Complete suppression of β cell GAD expression blocked the generation of diabetogenic T cells and protected islet grafts from autoimmune injury. Thus, β cell–specific GAD expression is required for the development of autoimmune diabetes in NOD mice, and modulation of GAD might, therefore, have therapeutic value in type 1 diabetes.
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Citations
Cited by
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
Kent, S. C., Chen, Y., Bregoli, L., Clemmings, S. M., Kenyon, N. S., Ricordi, C., Hering, B. J., & Hafler, D. A. (2005) · Nature · doi:10.1038/nature03625 · Cited by 409
Autoimmune Destruction of Pancreatic β Cells
Yoon, J.-W., & Jun, H.-S. (2005) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000178767.67857.63 · Cited by 308
Self-citationHeaden, D. M., Woodward, K. B., Coronel, M. M., Shrestha, P., Weaver, J. D., Zhao, H., Tan, M., Hunckler, M. D., Bowen, W. S., Johnson, C. T., et al. (2018) · Nature Materials · doi:10.1038/s41563-018-0099-0 · Cited by 175
Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic β-cells
Braun, M., Wendt, A., Birnir, B., Broman, J., Eliasson, L., Galvanovskis, J., Gromada, J., Mulder, H., & Rorsman, P. (2004) · The Journal of General Physiology · doi:10.1085/jgp.200308966 · Cited by 130
Metadata
- Authors
- Yoon, J.-W., Yoon, C.-S., Lim, H.-W., Huang, Q. Q., Kang, Y., Pyun, K. H., Hirasawa, K., Sherwin, R. S., & Jun, H.-S.
- Venue
- Science
- Published
- 1999-05-14
- Volume
- 284
- Issue
- 5417
- Pages
- 1183-1187
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079788829
- Cited by
- 247
- References
- 0
- FWCI
- 15.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yoon, J.-W., Yoon, C.-S., Lim, H.-W., Huang, Q. Q., Kang, Y., Pyun, K. H., Hirasawa, K., Sherwin, R. S., & Jun, H.-S. (1999). Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells. Science. https://doi.org/10.1126/science.284.5417.1183
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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