Bacterial Biofilms: A Common Cause of Persistent Infections
Abstract
Bacteria that attach to surfaces aggregate in a hydrated polymeric matrix of their own synthesis to form biofilms. Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. Studies of biofilms have revealed differentiated, structured groups of cells with community properties. Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
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A near-universal characteristic of biofilms, compared with their free-floating counterparts, is the greater resistance of their cells to chemical and physical insults.
“A near-universal characteristic of biofilms, compared with their free-floating counterparts, is the greater resistance of their cells to chemical and physical insults (31, 32).”
From <i>Candida albicans</i> Biofilms and Human Disease (2015) · cites this paper as [32]
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References 54 · Cited by 12,167
- Authors
- Costerton, J. W., Stewart, P. S., & Greenberg, E. P.
- Affiliations
- Montana State University (US)
- University of Iowa (US)
- Corresponding author
- Greenberg, E. P.
- Venue
- Science
- Published
- 1999-05-21
- Volume
- 284
- Issue
- 5418
- Pages
- 1318-1322
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2144440398
- Cited by
- 12,167
- References
- 54
- Citations by year
- 2026: 404 · 2025: 451 · 2024: 451 · 2023: 495 · 2022: 604 · 2021: 630 · 2020: 687 · 2019: 657 · 2018: 642 · 2017: 655 · 2016: 706 · 2015: 601 · 2014: 671 · 2013: 584 · 2012: 600
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Montana State University ScholarWorks (Montana State University) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (GM-59026, R01GM059026)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- bacterial biofilms, persistent infection, chronic bacterial infection, antimicrobial resistance, biofilm matrix, therapeutic target
- MeSH terms
- Anti-Bacterial Agents, Bacterial Infections, Cystic Fibrosis, Drug Resistance, Microbial, Equipment Contamination, Genes, Bacterial, Humans, Lung, Pseudomonas aeruginosa, Pseudomonas Infections, Biofilms
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