The DOI matches its Crossref record.
Self-Organization of Microtubule Asters Induced in Xenopus Egg Extracts by GTP-Bound Ran
Abstract
The nucleotide exchange activity of RCC1, the only known nucleotide exchange factor for Ran, a Ras-like small guanosine triphosphatase, was required for microtubule aster formation with or without demembranated sperm in Xenopus egg extracts arrested in meiosis II. Consistently, in the RCC1-depleted egg extracts, Ran guanosine triphosphate (RanGTP), but not Ran guanosine diphosphate (RanGDP), induced self-organization of microtubule asters, and the process required the activity of dynein. Thus, Ran was shown to regulate formation of the microtubule network.
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Cited by
HURP is part of a Ran-dependent complex involved in spindle formation
Koffa, M. D., Casanova, C. M., Santarella, R., Köcher, T., Wilm, M., & Mattaj, I. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.056 · Cited by 250
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity
Zhang, X., Ems-McClung, S. C., & Walczak, C. E. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0198 · Cited by 123
Microtubule assembly during mitosis – from distinct origins to distinct functions?
Meunier, S., & Vernos, I. (2012) · Journal of Cell Science · doi:10.1242/jcs.092429 · Cited by 112
Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons
Chen, W.-S., Chen, Y.-J., Huang, Y.-A., Hsieh, B.-Y., Chiu, H.-C., Kao, P.-Y., Chao, C.-Y., & Hwang, E. (2017) · Scientific Reports · doi:10.1038/srep42297 · Cited by 41
Casanova, C. M., Rybina, S., Yokoyama, H., Karsenti, E., & Mattaj, I. W. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-06-0624 · Cited by 30
Metadata
- Authors
- Ohba, T., Nakamura, M., Nishitani, H., & Nishimoto, T.
- Venue
- Science
- Published
- 1999-05-21
- Volume
- 284
- Issue
- 5418
- Pages
- 1356-1358
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064062498
- Cited by
- 302
- References
- 0
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
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